{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:53:01Z","timestamp":1791960781468,"version":"4.3.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The CRISPR Journal"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p>\n                    In July 2019, Victoria Gray became the first patient with sickle cell disease to receive a CRISPR-based cell therapy as a volunteer in the exa-cel clinical trial, sponsored by Vertex Pharmaceuticals and CRISPR Therapeutics. Barely four years later, the ensuing therapy, branded as Casgevy, received approval from regulatory agencies in Europe, the United States, and the Middle East, ushering in a new era of CRISPR-based medicines. During this period, scores of other clinical trials have been launched, including many actively recruiting patients across phase 1, phase 2, and phase 3 clinical trials around the world. In this brief Perspective, we collate the latest information on therapeutic clinical trials featuring CRISPR, base and prime editing, across a range of both\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    gene and cell therapies.\n                  <\/jats:p>","DOI":"10.1089\/crispr.2024.0081","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T10:00:21Z","timestamp":1729591221000},"page":"227-230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Five Years of Progress in CRISPR Clinical Trials (2019\u20132024)"],"prefix":"10.1177","volume":"7","author":[{"given":"Kevin","family":"Davies","sequence":"first","affiliation":[{"name":"The CRISPR Journal, Mary Ann Liebert Inc., New Rochelle, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Philippidis","sequence":"additional","affiliation":[{"name":"Genetic Engineering &amp; Biotechnology News, Mary Ann Liebert Inc., New Rochelle, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-3504","authenticated-orcid":false,"given":"Rodolphe","family":"Barrangou","sequence":"additional","affiliation":[{"name":"The CRISPR Journal, Mary Ann Liebert Inc., New Rochelle, New York, USA."},{"name":"North Carolina State University, Raleigh, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309676"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.add8643"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07800-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107454"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309149"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.07.007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/crispr.2024.0042"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","DOI":"10.1089\/crispr.2024.0082","article-title":"Give Cas a chance: an actionable path to a platform for CRISPR cures","volume":"7","author":"Urnov FD","year":"2024","unstructured":"Urnov FD. Give Cas a chance: an actionable path to a platform for CRISPR cures. CRISPR J, 2024; 7(this iss).","journal-title":"CRISPR J"}],"container-title":["The CRISPR Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/crispr.2024.0081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/crispr.2024.0081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/crispr.2024.0081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:00:41Z","timestamp":1777644041000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/crispr.2024.0081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1089\/crispr.2024.0081"],"URL":"https:\/\/doi.org\/10.1089\/crispr.2024.0081","relation":{},"ISSN":["2573-1599","2573-1602"],"issn-type":[{"value":"2573-1599","type":"print"},{"value":"2573-1602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]}}}