{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:18:04Z","timestamp":1788250684557,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract: Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Persistent localized dermatitis (PLD) or eczema flare-ups (EF) may occur in atopic dermatitis (AD) patients treated with dupilumab. They may reflect concomitant allergic contact dermatitis (ACD) exposed by the inhibition of the Th2 pathway by dupilumab in some cases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To evaluate the prevalence and etiology of these events and the impact of dupilumab on patch test outcome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    We performed patch tests on 54 AD patients treated with dupilumab and evaluated the prevalence and final diagnosis of EF and PLD as well as the patch test results.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    The patch test results were positive in 20\/54 (37.0%). 21\/54 patients (38.9%) had PLD and 12\/54 (22.2%) had EF. Ten of 54 (18.5%) had both conditions and 11\/54 (20.4%) had neither PLD nor EF. 64.5% of PLD involved the face. 83.9% patients with PLD and 90.9% patients with EF were diagnosed with inadequately controlled AD. 9.7% patients with PLD and 4.5% patients with EF were finally diagnosed with ACD. Nine of 21 (42.9%) patients patch tested twice were positive either before and\/or during dupilumab. Patch tests results changed over time in all of them.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Patch testing assisted us to exclude ACD as the cause of PLD\/EF in AD patients treated with dupilumab. Most PLD and EF were, however, diagnosed as poorly controlled AD. Dupilumab appeared to impact the patch test outcomes.\n                  <\/jats:p>","DOI":"10.1089\/derm.2022.0023","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T17:44:17Z","timestamp":1680284657000},"page":"315-322","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Patch Testing in Patients with Severe Atopic Dermatitis Treated with Dupilumab: A Multicentric Approach in Spain"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-1206","authenticated-orcid":false,"given":"Alexandre","family":"Docampo-Sim\u00f3n","sequence":"first","affiliation":[{"name":"From the,  Dermatology Department, Hospital General Universitario de Alicante, Alicante, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"S\u00e1nchez-Pujol","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Department, Hospital General Universitario de Alicante, Alicante, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Pastor-Nieto","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital General Universitario de Guadalajara, Faculty of Medicine and Health Sciences, Medicine and Medical Specialties Department, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gim\u00e9nez-Arnau","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital del Mar, Institut Mar d'Investigacions M\u00e8diques, Universitat Pompeu Fabra, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodr\u00edguez-Serna","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario La Fe, Valencia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Serra-Baldrich","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Miquel","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Arnau de Vilanova de Valencia, Valencia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"S\u00e1nchez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario de la Princesa, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Sanz-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Infanta Sof\u00eda, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Zaragoza-Ninet","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital General Universitario de Valencia, Valencia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"S\u00e1nchez-Pedre\u00f1o","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, El Palmar, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Gatica-Ortega","sequence":"additional","affiliation":[{"name":"Dermatology Department, Complejo Hospitalario Universitario de Toledo, Toledo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Fern\u00e1ndez-Redondo","sequence":"additional","affiliation":[{"name":"Dermatology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"C\u00f3rdoba-Guijarro","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gonz\u00e1lez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Araba, Vitoria-Gasteiz, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Department, Hospital General Universitario de Alicante, Alicante, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14673"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12358"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.148"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.009"},{"key":"e_1_3_1_7_2","article-title":"Perivascular clusters of Th2 cells and M2 macrophages in allergic contact dermatitis to methylchloroisothiazolinone and methylisothiazolinone","author":"Virgens AR","year":"2021","unstructured":"Virgens AR, , Goes HFO, , de Carvalho GC, et al. Perivascular clusters of Th2 cells and M2 macrophages in allergic contact dermatitis to methylchloroisothiazolinone and methylisothiazolinone. 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Dupilumab-induced extrafacial paradoxical persistent erythema in an atopic dermatitis patient. Dermat contact, atopic, Occup drug, 2021; 32(1S):E83\u2013E85. doi: 10.1097\/DER.0000000000000785.","journal-title":"Dermat contact, atopic, Occup drug"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.01.023"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.026"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.2613"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2022.02.018"},{"issue":"7","key":"e_1_3_1_21_2","first-page":"559","article-title":"The Spanish standard patch test series: 2016 update by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC)","volume":"107","author":"Hervella-Garc\u00e9s M","year":"2016","unstructured":"Hervella-Garc\u00e9s M, , Garc\u00eda-Gav\u00edn J, , Silvestre-Salvador JF. The Spanish standard patch test series: 2016 update by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC). 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