{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:27:31Z","timestamp":1789730851581,"version":"4.0.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"\n \n \n Abstract: Background:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare drug reaction characterized by a skin rash, eosinophilia, and organ involvement.\n <\/jats:p>\n \n \n \n Objective:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n Our purpose is to focus on the clinical and epidemiological characteristics of DRESS in the elderly and to identify the incriminated drugs.\n <\/jats:p>\n \n \n \n Methods:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n This is a retrospective study including patients, hospitalized for DRESS with a RegiSCAR \u22654. The population was divided into 2 groups according to age: 65 years or older (G1) and <65 years (G2). The statistical study was performed using the comparative and multivariate analysis.\n <\/jats:p>\n \n \n \n Results:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n We included 55 patients (30.9% G1 and 69.1% G2). Skin manifestations were comparable in both groups. Lymphadenopathy was less common in G1 with a statistically significant difference (\n P<\/jats:italic>\n \u2009=\u20090.012). Renal impairment was more frequent in the elderly with a statistically significant result (\n P<\/jats:italic>\n \u2009=\u20090.005). DRESS in the elderly group was significantly associated with the occurrence of sepsis (\n P<\/jats:italic>\n \u2009=\u20090.008). Allopurinol was the most common culprit associated with DRESS in G1 (\n P<\/jats:italic>\n \u2009=\u20090.001). Relapses and recurrences were comparable in both groups (\n P<\/jats:italic>\n \u2009=\u20090.71).\n <\/jats:p>\n \n \n \n Conclusions:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n DRESS in the elderly is associated with a high risk of complications, mainly kidney involvement and sepsis. Allopurinol is the most incriminated drug.\n <\/jats:p>","DOI":"10.1089\/derm.2022.0032","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:52:30Z","timestamp":1693914750000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of DRESS Syndrome in the Elderly: A Comparative Study of 55 Patients"],"prefix":"10.1177","volume":"35","author":[{"given":"Emna","family":"Bahloul","sequence":"first","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-583X","authenticated-orcid":false,"given":"Khaoula","family":"Trimeche","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Sellami","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Hammami","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten","family":"Hayder","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Chaabouni","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Amouri","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahmen","family":"Masmoudi","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha","family":"Mseddi","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Boudeya","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Turki","sequence":"additional","affiliation":[{"name":"From the Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.052"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_582_17"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.01694.x"},{"key":"e_1_3_1_6_2","unstructured":"Adverse Effects of Medications in Elderly Subjects\u2014National Academy of Medicine: An Institution in Its Time. Available from: https:\/\/www.academie-medecine.fr\/effets-indesirables-des-medicaments-chez-lessujets-ages\/ [Last accessed: July 31 2022]."},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.03.006"},{"issue":"5","key":"e_1_3_1_8_2","first-page":"1071","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction","volume":"169","author":"Kardaun SH","year":"2013","unstructured":"Kardaun SH, , Sekula P, , Valeyrie-Allanore L, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol. 2013; 169(5):1071\u20131080.","journal-title":"Results from the prospective RegiSCAR study. 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Management and treatment outcome of DRESS patients in Europe: an International Multicentre Retrospective Study of 141 cases. J Eur Acad Dermatol Venereol. 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