{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:43:47Z","timestamp":1793411027048,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    In the wake of the emerging development of biologics in atopic dermatitis (AD), herpes zoster (HZ) infection has been reported as a treatment-related adverse event.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Objectives:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>This study aims at investigating the association between AD and HZ, and the risk factors within.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Methods:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>28,677 participants with AD from the Taiwan National Health Insurance Research Database 2000\u20132015 were enrolled. Risk of HZ infection was compared in the study cohort (with AD) and the control cohort (without AD). Further analyses were conducted in gender-, age-, and treatment strategy-stratified subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Results:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Significantly higher adjusted hazard ratios (aHRs) of HZ infection were revealed in AD patients (aHR\u2009=\u20092.303,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and remained this trend in gender- and age-stratified models. All AD groups, irrespective of the treatment type, had higher aHRs (AD without systemic treatment: aHR\u2009=\u20092.356,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001; AD with systemic treatment: aHR\u2009=\u20092.182,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with those without AD. However, no differences in HZ risk were shown between each treatment type.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Conclusions:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Risk of HZ infection in AD is higher irrespective of treatment type. Considering that AD\n                      <jats:italic toggle=\"yes\">per se<\/jats:italic>\n                      increases susceptibility to HZ infection, the administration of biologics requires careful considerations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/derm.2022.0094","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T11:18:32Z","timestamp":1681903112000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Atopic Dermatitis as a Risk Factor for Herpes Zoster Infection Independent of Treatment: A Nationwide Population-Based Cohort Study"],"prefix":"10.1177","volume":"34","author":[{"given":"Shou-En","family":"Wu","sequence":"first","affiliation":[{"name":"From the,  Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsien","family":"Chen","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Public Health, National Defense Medical Center, Taipei, Taiwan."},{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."},{"name":"Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwo-Jang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."},{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan."},{"name":"Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Huei","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."},{"name":"Department of Microbiology &amp; Immunology, National Defense Medical Center, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-An","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan."},{"name":"Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"School of Public Health, National Defense Medical Center, Taipei, Taiwan."},{"name":"Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."},{"name":"Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan."},{"name":"Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-7757","authenticated-orcid":false,"given":"Chih-Tsung","family":"Hung","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan."},{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"issue":"3","key":"e_1_3_2_2_2","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9899.1000110","article-title":"Th2 cytokines and atopic dermatitis","volume":"2","author":"Brandt EB","year":"2011","unstructured":"Brandt EB, , Sivaprasad U. 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