{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:12:37Z","timestamp":1777554757502,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:underline>Abstract: Background:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>Benzophenone (BZP)-3 and BZP-4 are ultraviolet (UV) absorbers used in sunscreens and personal care products (PCPs) and may cause allergic contact dermatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Objective:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>To characterize positive patch test reactions to BZP-3 (10% in petrolatum [pet]) and BZP-4 (2% pet) in a screening allergen series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Methods:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>Retrospective analysis of patients tested to BZP-3 and BZP-4 was conducted by the North American Contact Dermatitis Group from 2013 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Results:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Of 19,618 patients patch tested to BZP-3 and BZP-4, 103 (0.5%) and 323 (1.6%) had positive reactions, respectively: 413 (2.1%) reacted to at least 1 BZP (BZP-positive patient). As compared with BZP-negative patients, BZP-positive patients were significantly more likely to have a history of hay fever (39.3% vs 33.4%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0134), history of atopic dermatitis (39.8% vs 30.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0001), and facial involvement (37.4% vs 32.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0272). Most reactions were currently clinically relevant (BZP-3: 90.4%; BZP-4: 65.8%). Common identified sources included PCPs and sunscreens. Coreactivity between BZP-3 and BZP-4 was low: 13.5% (14\/104) of BZP-3\u2013positive patients were allergic to BZP-4 and 4.3% (14\/322) of BZP-4\u2013positive patients were allergic to BZP-3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Conclusions:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>Eight-year prevalence of BZP positivity was 2.1%. Reactions were frequently clinically relevant and linked to PCPs and sunscreens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/derm.2022.29013.ewa","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T10:49:56Z","timestamp":1674730196000},"page":"105-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Patch Testing with Benzophenone-3 and -4: The North American Contact Dermatitis Group Experience, 2013\u20132020"],"prefix":"10.1177","volume":"34","author":[{"given":"Erin M.","family":"Warshaw","sequence":"first","affiliation":[{"name":"From the,  Department of Dermatology, Park Nicollet\/Health Partners Health Services, Minneapolis, Minnesota, USA"},{"name":"Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, 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Dermatology, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel G.","family":"DeKoven","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margo J.","family":"Reeder","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Houle","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Centre Hospitalier Universitaire de Qu\u00e9bec, Laval 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