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Allergic contact dermatitis can be elicited by various hair dye-related allergens, though the main problem remains with\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -phenylenediamine and related aromatic amines. If allergy is suspected, patch testing identifies the responsible hapten. Individuals sensitized to specific permanent hair dyes substances should avoid the exposure to these chemicals, but also be aware of possible cross-sensitization to other similar compounds. Cross-reactions detected in patch-tested populations indicate that one cannot safely use alternatives, although cross-reactivity is not always clinically relevant. An open application hair dye allergy self-test is recommended by manufacturers for early detection of allergy predisposition in consumers, although the lack of standardized conditions makes the efficacy of this process doubtful. Appropriate use of hand gloves, especially nitrile, is the most efficient prevention measure for professional hand eczema. In this systematic review, we focus on cross-reactions among hair dye-related allergens and make an attempt to answer some, frequently encountered by physicians, questions, while presenting the prevalence of the hair dye-related allergens.\n                  <\/jats:p>","DOI":"10.1089\/derm.2023.0019","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T15:20:14Z","timestamp":1687533614000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hair Dyes Sensitization and Cross-Reactions: Challenges and Solutions: A Systematic Review of Hair Dye Allergens' Prevalence"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-0762","authenticated-orcid":false,"given":"Antonios","family":"Tsimpidakis","sequence":"first","affiliation":[{"name":"From the,  1st Department of Dermatology and Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Katoulis","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology, Attiko Hospital, National and Kapodistrian University of Athens, Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Electra","family":"Nicolaidou","sequence":"additional","affiliation":[{"name":"From the,  1st Department of Dermatology and Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Rigopoulos","sequence":"additional","affiliation":[{"name":"From the,  1st Department of Dermatology and Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stratigos","sequence":"additional","affiliation":[{"name":"From the,  1st Department of Dermatology and Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stamatis","family":"Gregoriou","sequence":"additional","affiliation":[{"name":"From the,  1st Department of Dermatology and Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2015.1076434"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2003.11.003"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S90265"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06511.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.10.002"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00134.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14236"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics9020041"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.86709"},{"key":"e_1_3_1_11_2","unstructured":"Commission Directive 2009\/130\/EC Amending Council Directive 76\/768\/EEC Concerning Cosmetic Products for the Purpose of Adapting Annex III Thereto to Technical Progress. 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