{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:38:37Z","timestamp":1781635117254,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract: Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Radiodermatitis is a common side effect of breast cancer radiotherapy; however, there is no current consensus regarding an effective standard therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To evaluate the efficacy of topical ectoin versus dexpanthenol in the management of acute radiodermatitis after breast cancer radiotherapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Fifty patients randomly used dexpanthenol 5% cream (25 patients), or ectoin 7% cream (25 patients), applied twice daily to the irradiated area during and for 2 weeks after radiotherapy. The study was stratified by the radiotherapy schedule and was double-blind. Radiodermatitis grade, radiation-associated symptoms, and adverse events were assessed weekly during radiotherapy and 2 weeks thereafter. Skin-related quality of life (QOL) scores were measured using the Skindex-16 questionnaire.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Both agents were effective in preventing severe radiodermatitis (\u2265G3). Ectoin had a lower radiodermatitis grade level than dexpanthenol, with a significant difference at week 2 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.008). Radiation-associated pain (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.003) and itching (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.001) were lower with ectoin than dexpanthenol. Side effects were not significantly different between the 2 treatments (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.107). Ectoin showed less QOL impairment than dexpanthenol. The radiation schedule was an independent predictor for radiodermatitis persistence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Ectoin showed some clinical benefit over dexpanthenol in improving radiation dermatitis and the radiation schedule is a predictor of radiodermatitis persistence.\n                  <\/jats:p>","DOI":"10.1089\/derm.2023.0055","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T11:24:55Z","timestamp":1696418695000},"page":"516-524","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Topical Ectoin versus Topical Dexpanthenol for Managing Acute Radiodermatitis Associated with Breast Cancer Radiotherapy: A Randomized Double-Blind Study"],"prefix":"10.1177","volume":"34","author":[{"given":"Nagwa E.","family":"Abd Elazim","sequence":"first","affiliation":[{"name":"From the,  Department of Dermatology, Venereology and Andrology, Assiut University Hospital, Assiut, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-6358","authenticated-orcid":false,"given":"Sara M.","family":"Awad","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Venereology and Andrology, Assiut University Hospital, Assiut, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha S.","family":"El-Naggar","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Nuclear Medicine, Assiut University Hospital, Assiut, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania H.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Venereology and Andrology, Assiut University Hospital, Assiut, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.15.1143"},{"issue":"7","key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s11136-017-1526-4","article-title":"Patient-reported symptoms of radiation dermatitis during breast cancer radiotherapy: a pilot study","volume":"26","author":"Lee J","year":"2017","unstructured":"Lee J, , Park W, , Choi DH, et al. 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