{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:31:50Z","timestamp":1783758710665,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract: Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Botanicals are increasingly incorporated into skincare products. Although allergic contact dermatitis due to botanicals is recognized, data describing the prevalence of positive patch tests to botanicals are sparse.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To report the Mayo Clinic experience of patch testing to selected botanical products in the standard, extended standard, fragrance, and plant series.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    IRB-approved retrospective study of the Mayo Clinic experience with patch testing to botanicals from 1997 to 2017.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    In total, 12,169 people were patch tested to botanicals in the standard, extended standard, fragrance, and plant series; 4032 were men and 8137 were women. The mean age of the population tested was 54 (standard deviation 17.7) years. Almost 11% (1320\/12,169) of the patch-tested population exhibited positive reactions to at least 1 botanical agent. Myroxylon pereirae resin 25% was the most common positive allergen in the series. Patients who had positive reactions to at least 1 botanical agent were more (19.8%) likely to have a positive reaction to at least 1 additional botanical than those patients who did not have any positive tests. Most patients presented with generalized involvement (334) or involvement of the hands (284) or face (232).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Physicians should be aware of the high prevalence of allergic contact dermatitis and patch test positivity associated with botanical products.\n                  <\/jats:p>","DOI":"10.1089\/derm.2023.0109","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T16:45:35Z","timestamp":1701103535000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Results of Patch Testing to Botanicals: Review of the Mayo Clinic Experience over 2 Decades (1997\u20132017)"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-6432","authenticated-orcid":false,"given":"Anagha","family":"Bangalore-Kumar","sequence":"first","affiliation":[{"name":"From the,  Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio F.","family":"Jin","sequence":"additional","affiliation":[{"name":"Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Kunkel","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishad","family":"Sathe","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Dermatology, University of Minnesota, Minneapolis, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3034-8626","authenticated-orcid":false,"given":"Matthew R.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Drage","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Youssef","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-0357","authenticated-orcid":false,"given":"Yul W.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Scottsdale, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Yiannias","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mayo Clinic, Scottsdale, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Killian","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.P.","family":"Davis","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"Center for Drug Evaluation and Research. What Is a Botanical Drug? [U.S. Food and Drug Administration Website]. October 24 2022. Available at https:\/\/www.fda.gov\/about-fda\/center-drug-evaluation-and-research-cder\/what-botanical-drug. Accessed June8 2023."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000175"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2020.02.009"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12171"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12939"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.04009"},{"issue":"17","key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1001\/jama.2022.18440","article-title":"Almost all \u201cnatural\u201d skin care products contain contact allergens","volume":"328","author":"Slomski A","year":"2022","unstructured":"Slomski A. Almost all \u201cnatural\u201d skin care products contain contact allergens. JAMA. 2022; 328(17):1677.","journal-title":"JAMA"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13253"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13119"},{"key":"e_1_3_1_11_2","unstructured":"Grand View Research. Botanical Ingredients Market Size Share & Trends Analysis Report by Source (Spices Flowers) by Form (Powder Liquid) by Application (Food & Beverage Personal Care & Cosmetics) by Region and Segment Forecasts 2023\u20132030. 2023. Available at: https:\/\/www.grandviewresearch.com\/industry-analysis\/botanical-ingredients-market. Accessed June8 2023."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12124"},{"key":"e_1_3_1_13_2","unstructured":"Grand View Research. Essential Oils Market Size Share & Trends Analysis Report by Application (Food & Beverages Spa & Relaxation) by Product (Orange Peppermint) by Sales Channel And Segment Forecasts 2020\u20132027. 2023. Available at: https:\/\/www.grandviewresearch.com\/industry-analysis\/essential-oils-market. 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Modernization of Cosmetics Regulation Act of 2022 [U.S. Food and Drug Administration Website]. April 14 2023. Available at: https:\/\/www.fda.gov\/cosmetics\/cosmetics-laws-regulations\/modernization-cosmetics-regulation-act-2022. Accessed June8 2023."},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03245.x"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000193"},{"issue":"1536","key":"e_1_3_1_29_2","first-page":"86","article-title":"Patch testing to plants: sensitisation associated with exposure to plants, essential oils and botanicals in cosmetics","volume":"134","author":"Murphy VL","year":"2021","unstructured":"Murphy VL, , Patel DC, , Lamb SR, et al. Patch testing to plants: sensitisation associated with exposure to plants, essential oils and botanicals in cosmetics. N Z Med J. 2021; 134(1536):86\u201399.","journal-title":"N Z Med J"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/derm.2023.0109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/derm.2023.0109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/derm.2023.0109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:07:11Z","timestamp":1777399631000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/derm.2023.0109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2,1]]}},"alternative-id":["10.1089\/derm.2023.0109"],"URL":"https:\/\/doi.org\/10.1089\/derm.2023.0109","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]}}}