{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:13:54Z","timestamp":1789092834384,"version":"build-2803163510"},"reference-count":59,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract: Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Chemotherapeutic drugs can lead to a wide spectrum of cutaneous findings, ranging from nonimmune toxic reactions to severe immune-mediated hypersensitivity reactions. The aim of this study was to evaluate the clinical, histopathological features, and prognosis of toxic skin reactions to chemotherapeutic drugs and to compare them with characteristics of immune-mediated reactions in children with malignancies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    The medical records of all children with cancer who experienced skin reactions after chemotherapy administration and diagnosed as a toxic skin reaction between 2010 and 2022 were retrospectively analyzed. The diagnosis was re-evaluated and differentiated from other similar disorders by using clinical manifestations, photodocumentation, and histopathological findings.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    A total of 17 children aged 2\u201317 years were involved: toxic erythema of chemotherapy (TEC) in 14 children, methotrexate-induced epidermal necrosis in 2 children, and toxic epidermal necrolysis (TEN)-like TEC in 1 child. The most commonly implicated drug was methotrexate. Most patients recovered rapidly after drug cessation and supportive measures. In 10 of the 17 patients, reintroduction of the culprit chemotherapeutic drug at reduced doses or increased dosage intervals was possible without any recurrence. Six patients could not receive further doses since they deceased due to sepsis and other complications.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Cutaneous toxic eruptions to chemotherapeutic drugs may present with a severe phenotype resembling Stevens\u2013Johnson syndrome\/TEN. An accurate diagnosis prevents potentially harmful therapeutic interventions, withholding of chemotherapy, and erroneous assignment of drug allergies.\n                  <\/jats:p>","DOI":"10.1089\/derm.2023.0258","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:05:21Z","timestamp":1704193521000},"page":"275-287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Toxic Skin Reactions Should Be Differentiated from Allergic Reactions to Chemotherapeutic Drugs in Children: A Case Series and Review of the Literature"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0486-0422","authenticated-orcid":false,"given":"Aylin Kont","family":"\u00d6zhan","sequence":"first","affiliation":[{"name":"From the,  Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Demirhan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology, Mersin City Training and Research Hospital, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"Arikoglu","sequence":"additional","affiliation":[{"name":"From the,  Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feryal","family":"Karahan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadime Eda G\u00f6kalp","family":"Sat\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazan","family":"Tokmeci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology, Ad\u0131yaman University Training and Research Hospital, Ad\u0131yaman, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beg\u00fcmhan Demir","family":"G\u00fcndo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Dr. Beh\u00e7et Uz Pediatric Diseases and Surgery Training and Research Hospital, \u0130zmir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysu \u0130lhan","family":"Yalaki","sequence":"additional","affiliation":[{"name":"From the,  Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veysi","family":"Akbey","sequence":"additional","affiliation":[{"name":"From the,  Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin Yuyucu","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semanur","family":"Kuyucu","sequence":"additional","affiliation":[{"name":"From the,  Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02440.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.018"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020323"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.572572"},{"key":"e_1_3_1_6_2","first-page":"e244","article-title":"Toxic erythema of chemotherapy with periorbital and perioral involvement","volume":"53","author":"Tay EY","year":"2012","unstructured":"Tay EY, , Lim YL. 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