{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:18:17Z","timestamp":1777555097732,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract: Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact Dermatitis caused by linalool hydroperoxides is insufficiently investigated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objectives:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Patients who previously had a positive (patients) and a negative (controls) patch test reaction to linalool hydroperoxides 1.0% in petrolatum were patch tested with a dilution series of linalool hydroperoxides preparations and asked to perform ROAT twice daily with 3 concentrations of linalool hydroperoxides creams and a negative control cream for 28 days. The creams contain 44, 140, and 440 PPM of linalool hydroperoxides, representing real-world doses reported in consumer products.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Of all 47 participants, 31 were linalool hydroperoxides contact allergy patients, and 16 were controls. One patient had a positive ROAT reaction in the area where cream at the highest concentration of linalool hydroperoxides was applied for 28 days.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Repeated exposure to creams containing linalool hydroperoxides at real-life concentrations could rarely elicit an allergic reaction on intact skin after 4 weeks.\n                  <\/jats:p>","DOI":"10.1089\/derm.2023.0286","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T12:43:55Z","timestamp":1708605835000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Allergic Contact Dermatitis to Linalool Hydroperoxides: Pitfalls in the Diagnostic Process\u2014Findings from a Repeated Open Application Test Study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-2988","authenticated-orcid":false,"given":"Thanisorn","family":"Sukakul","sequence":"first","affiliation":[{"name":"From the,  Department of Occupational and Environmental Dermatology, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"From the,  Department of Occupational and Environmental Dermatology, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-9274","authenticated-orcid":false,"given":"Martin","family":"Mowitz","sequence":"additional","affiliation":[{"name":"From the,  Department of Occupational and Environmental Dermatology, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kiuru","sequence":"additional","affiliation":[{"name":"From the,  Department of Occupational and Environmental Dermatology, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"From the,  Department of Occupational and Environmental Dermatology, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000471"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-020-08790-w"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112687"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00913.x"},{"issue":"12","key":"e_1_3_1_6_2","first-page":"1697","article-title":"Contact allergens formed on air exposure of linalool","volume":"17","author":"Skold M","year":"2004","unstructured":"Skold M, , Borje A, , Harambasic E, et al. Contact allergens formed on air exposure of linalool. Identification and quantification of primary and secondary oxidation products and the effect on skin sensitization. Chem Res Toxicol. 2004; 17(12):1697\u20131705.","journal-title":"Identification and quantification of primary and secondary oxidation products and the effect on skin sensitization"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01402.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00605.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13980"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.030"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000763"},{"key":"e_1_3_1_12_2","unstructured":"SCCS (Scientific Committee on Consumer Safety) Opinion on Fragrance Allergens in Cosmetic Products December 13\u201314 2011."},{"key":"e_1_3_1_13_2","unstructured":"Commission Regulation (EU) 2023\/1545 of 26 Amending Regulation (EC) No 1223\/2009 As Regards Labelling of Fragrance Allergens in Cosmetic Products July 26 2023."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.03.028"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.06.056"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-8066-3"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13276"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12738"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1986.tb01229.x"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12163"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3451"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13689"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb01232.x"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18224"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_3_1_26_2","volume-title":"Manual of Contact Dermatitis","author":"Fregert S","year":"1981","unstructured":"Fregert S. 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