{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:19:05Z","timestamp":1777555145143,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>\n                    <jats:underline>Abstract: Background and Objective:<\/jats:underline>\n                  <\/jats:title>\n                  <jats:p>Atopic Dermatitis (AD) is the most prevalent inflammatory skin disorder resulting in an intense impact on patients quality of life. The aim of this study is to evaluate the clinical meaning of the DLQI scores documented between different phenotypes of AD patients under biologic therapy with Dupilumab.<\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Method:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    We conducted a retrospective analysis of 209 patients with AD treated with Dupilumab for 2 years. These patients were categorized into different clinical phenotypes. Severity of the disease was assessed by using the Eczema Area and Severity Index (EASI), Numerical Scale Rating (NRS) for sleep (NRS sleep), pruritus (NRS pruritus) and Dermatology Life Quality Index (DLQI) at baseline and subsequently at 4,12 and 24 months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Our results show that the higher DLQI scores (mean: 18.6, range:9-30) achieved at T0 are associated with a prurigo nodularis AD pattern, while after 24 months (T3) of therapy with Dupilumab, the worst quality of life index results were reported in Flexural and Head-Neck combined clinical phenotypes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Quality of life is probably what matters most as an overall endpoint in AD. Assessing the clinical meaning of DLQI scores across different AD phenotypes could be a further aid when considering decision making factors in patient management.\n                  <\/jats:p>","DOI":"10.1089\/derm.2023.0357","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T12:08:34Z","timestamp":1714133314000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Clinical Meaning of Dermatology Life Quality Index Scores between Different Phenotypes of Atopic Dermatitis in Patients before and after Biologic Therapy with Dupilumab"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-7720","authenticated-orcid":false,"given":"Filomena","family":"Russo","sequence":"first","affiliation":[{"name":"From the,  Department of Dermatology, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Cioppa","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Milanesi","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Azienda USL Toscana Centro, Pistoia-Prato, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Fondazione Policlinico \u201cTor Vergata,\u201d Rome, Italy."},{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Massimiliano","family":"D'Erme","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Livorno Hospital, Livorno, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-766X","authenticated-orcid":false,"given":"Natale","family":"Schettini","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Cocuroccia","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Sordi","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarita","family":"Panebianco","sequence":"additional","affiliation":[{"name":"Medical direction, IDI-IRCCS-FLMM, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Talamonti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Fondazione Policlinico \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Paganini","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Fondazione Policlinico \u201cTor Vergata,\u201d Rome, Italy."},{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ornella","family":"De Pit\u00e0","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rita","family":"Giampetruzzi","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Luca","family":"Scaglione","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000592"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406223211002979"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-0488.19.06527-1"},{"issue":"5","key":"e_1_3_1_6_2","first-page":"997","article-title":"The Dermatology Life Quality Index 1994\u20132007: A comprehensive review of validation data and clinical results","volume":"159","author":"Basra MK","year":"2008","unstructured":"Basra MK, , Fenech R, , Gatt RM, et al. The Dermatology Life Quality Index 1994\u20132007: A comprehensive review of validation data and clinical results. 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