{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:18:32Z","timestamp":1777555112497,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:\nBackground:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Atopic dermatitis (AD) can present with open-angle glaucoma, but powerful evidence to support their causal relationship is absent.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To investigate the causal association of AD with primary open-angle glaucoma (POAG).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    A bidirectional 2-sample Mendelian randomization (MR) study was performed with the software R.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Eighteen single nucleotide polymorphisms (SNPs) were used in the forward MR analysis with AD as exposure. The inverse-variance weighted (IVW) method produced a result that genetically predicted AD was not associated with POAG (odds ratio [OR]\u2009=\u20091.10, 95% confidence interval [CI]: 0.95\u20131.27,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.215). Fifty-one SNPs were used in the reverse MR analysis with POAG as exposure. The IVW method yielded a result that genetically predicted POAG was not correlated with AD (OR\u2009=\u20090.98, 95% CI: 0.95\u20131.01,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.191). The bidirectional causal effect estimates were consistent with supplementary MR methods (MR-Egger, weighted median, simple mode, and weighted mode). The sensitivity analysis showed stable results.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    This bidirectional 2-sample MR study did not give evidence of causal association between AD and POAG.\n                  <\/jats:p>","DOI":"10.1089\/derm.2023.0380","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T13:59:57Z","timestamp":1708696797000},"page":"508-512","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["No Evidence of Causal Association between Atopic Dermatitis and Primary Open-Angle Glaucoma: A Bidirectional Two-Sample Mendelian Randomization Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Xingbao","family":"Luan","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Cui","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipan","family":"Fan","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaopeng","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-8657","authenticated-orcid":false,"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad339"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.07.006"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.10.023"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00455-5"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.21899"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.08.023"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10618"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12292"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.074"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.01.035"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000069"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14193"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2019.31.1.37"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3034"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3424"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20851-4"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt084"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000559"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18429"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18345"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.10.004"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2020.01.002"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960050494011"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab329"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16796"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.05.023"},{"key":"e_1_3_1_30_2","article-title":"Association of atopic dermatitis with conjunctivitis and other ocular surface diseases: a bidirectional two-sample Mendelian randomization study [published online ahead of print, 2023 Mar 15]","author":"Zhou W","year":"2023","unstructured":"Zhou W, , Cai J, , Li Z, et al. Association of atopic dermatitis with conjunctivitis and other ocular surface diseases: a bidirectional two-sample Mendelian randomization study [published online ahead of print, 2023 Mar 15]. J Eur Acad Dermatol Venereol. 2023;10.1111\/jdv.19048. doi:10.1111\/jdv.19048","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_3_1_31_2","article-title":"Atopic dermatitis and risk of 14 site-specific cancers: a Mendelian randomization study [published online ahead of print, 2023 Jul 21]","author":"Liu Q","year":"2023","unstructured":"Liu Q, , Chen L, , Wang Y, et al. Atopic dermatitis and risk of 14 site-specific cancers: a Mendelian randomization study [published online ahead of print, 2023 Jul 21]. 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