{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:20:12Z","timestamp":1777555212385,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"\n \n \n Abstract:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n \n \n Background:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n Atopic dermatitis (AD) is a chronic inflammatory skin disease that significantly affects patients\u2019 quality of life (QoL). Limited data exists on the effects AD poses on sexual well-being.\n <\/jats:p>\n \n \n \n Objective:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n To evaluate the impact of moderate-to-severe atopic dermatitis (MtS-AD) on sexual well-being and assess the efficacy of advanced therapies, specifically abrocitinib and dupilumab, in improving sexual health.\n <\/jats:p>\n \n \n \n Methods:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n In this retrospective study, medical records and responses to an 8-item questionnaire assessing sexual well-being in patients with MtS-AD were reviewed at baseline and after 52 weeks of treatment with abrocitinib or dupilumab.\n <\/jats:p>\n \n \n \n Results:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n In total, 44 patients were included (mean age: 30.8, 43.2% female). Before treatment, 88.6% reported AD affected their sexual well-being, including feeling unattractive (79.5%), avoiding sexual activity (68.2%), feeling ashamed or embarrassed (68.2%), and experiencing rejection (56.8%). After 52 weeks of treatment with abrocitinib or dupilumab, these negative perceptions and behaviors significantly reduced.\n <\/jats:p>\n \n \n \n Conclusions:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n MtS-AD negatively impacts patients\u2019 sexual well-being; however, advanced therapies like abrocitinib and dupilumab can significantly improve the sexual lives of affected patients, highlighting the broader benefits of these treatments on QoL.\n <\/jats:p>","DOI":"10.1089\/derm.2024.0362","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T03:38:12Z","timestamp":1733369892000},"page":"636-640","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patients\u2019 Perception of the Impact of Moderate to Severe Atopic Dermatitis on Their Sexual Well-Being: Comparison of Pre- and Posttreatment with Advanced Therapies"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8383-2295","authenticated-orcid":false,"given":"Nicole","family":"Asamoah","sequence":"first","affiliation":[{"name":"From the, Michael G. DeGroote School of Medicine, McMaster University, St. Catharines, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devyani","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Buentiempo","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Carleton University, Ottawa, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohannad","family":"Abu-Hilal","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, McMaster University, Hamilton, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2024.01.002"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20210194"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14763"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2018.1498329"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.07.006"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000104263"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/life11121314"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121708"},{"key":"e_1_3_1_10_2","first-page":"614","article-title":"Atopic dermatitis and sexual behavior of women","volume":"68","author":"Astafieva N","year":"2013","unstructured":"Astafieva N, , Eremina M, , Kobzev D. Atopic dermatitis and sexual behavior of women. Allergy. 2013; 68:614\u2013615.","journal-title":"Allergy"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000161"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0171-3"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13689"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.11.1327"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2010.484463"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000617"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v104.10321"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20031918"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/derm.2024.0362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/derm.2024.0362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/derm.2024.0362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:09:15Z","timestamp":1777399755000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/derm.2024.0362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1089\/derm.2024.0362"],"URL":"https:\/\/doi.org\/10.1089\/derm.2024.0362","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]}}}