{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:17:39Z","timestamp":1783048659025,"version":"3.54.6"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Hair dyes are a commonly used cosmetic product and an important cause of allergic contact dermatitis (ACD). Primary hair dye agents, paraphenylenediamine (PPD) and other aromatic amines, are potent contact sensitizers. Despite some hair dyes being advertised as all natural or allergen-free, patients still present with hair dye contact allergy following the use of these products. We hypothesized that these products may contain cross-reactive ingredients not tested on standard series or undisclosed ingredients such as trace amounts of the allergens.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    We aimed to test hair dyes marketed and sold in the United States as \u201cPPD-free\u201d for the presence and quantity of common hair dye allergens and ingredients, including p-phenylenediamine, m-aminophenol, p-aminophenol, toluene-2,5-diamine sulfate, 2-nitro-p-phenylenediamine, and 2-hydroxy-1,4-naphthoquinone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    We tested best-selling hair dyes advertised as \u201cPPD-free\u201d for common allergens through high-performance liquid chromatography coupled to high-resolution mass spectrometry.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    In 7 out of 51 hair dye products, we detected a compound that was not present on the ingredient list. Five products contained PPD despite no mention of PPD on the ingredient list and 4 being labeled \u201cPPD-free.\u201d One of these products contained PPD levels higher than 2% by weight, while the rest contained trace levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    These findings may help guide dermatologists in counseling patients with ACD about the importance of performing allergy alert testing before the use of a new hair dye product, regardless of how it is commercially advertised or labeled.\n                  <\/jats:p>","DOI":"10.1089\/derm.2024.0542","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T05:31:44Z","timestamp":1750743104000},"page":"421-427","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Contact Allergens in \u201cPPD-Free\u201d Hair Dyes"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9768-3831","authenticated-orcid":false,"given":"Carli D.","family":"Needle","sequence":"first","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C.","family":"Milam","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-1998","authenticated-orcid":false,"given":"Aryeh","family":"Korman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra F.","family":"Flamm","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora K.","family":"Karagounis","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.160253"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00362.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39042.643206.BE"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2020.1802740"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.3.316"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S90265"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12164"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.100556"},{"issue":"4","key":"e_1_3_2_10_2","first-page":"189","article-title":"Alternative hair-dye products for persons allergic to para-phenylenediamine","volume":"22","author":"Scheman A","year":"2011","unstructured":"Scheman A, , Cha C, , Bhinder M. Alternative hair-dye products for persons allergic to para-phenylenediamine. DERM. 2011; 22(4):189\u2013192.","journal-title":"DERM"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2024.0384"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0140"},{"key":"e_1_3_2_13_2","unstructured":"CIR Report Data Sheet: Safety Assessment of p-Phenylenediamine p-Phenylenediamine HCl and p-Phenylenediamine Sulfate as Used in Cosmetics. Available from: https:\/\/online.personalcarecouncil.org\/ctfa-static\/online\/lists\/cir-pdfs\/TR901.pdf [Last accessed: April10 2024]."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0015-6264(74)90367-8"},{"key":"e_1_3_2_15_2","unstructured":"Ezendam J Park M Salverda-Nijhof J. A Quantitative Approach to Assess the Risk of Skin Sensitization from Hair Dye Ingredients: A Case Study Using p-Phenylenediamine (PPD). Rijksinstituut voor Volksgezondheid en Milieu RIVM; 2013. Available from: https:\/\/rivm.openrepository.com\/handle\/10029\/311523 [Last accessed: April8 2024]."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12302-015-0044-7"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.209"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.186495"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12077"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0019"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12354"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000405"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/derm.2024.0542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/derm.2024.0542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/derm.2024.0542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:45:31Z","timestamp":1783046731000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/derm.2024.0542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1089\/derm.2024.0542"],"URL":"https:\/\/doi.org\/10.1089\/derm.2024.0542","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}