{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T10:43:22Z","timestamp":1786185802406,"version":"build-2736575974"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Chronic spontaneous urticaria (CSU), a debilitating condition, is often treated with omalizumab for antihistamine-refractory cases. Atopy subtypes (extrinsic\/intrinsic) may influence CSU clinical features and treatment responses, but remain understudied.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To assess the clinical relevance of atopy subtypes in CSU and their link to omalizumab response.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Retrospective analysis of 210 omalizumab-treated CSU patients assessed through allergen-specific immunoglobulin E (IgE), total IgE, personal\/family history, and atopic signs. Groups: nonatopic, extrinsic, or intrinsic atopic. Treatment response, onset speed, and safety profiles were evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Atopy prevalence was 70% (extrinsic: 50.5%, intrinsic: 19.5%). Extrinsic atopic patients showed higher personal\/family urticaria history and annular\/semi-annular wheals. Nonatopic patients were older, with more red plaques\/patches and higher IgG-anti-thyroid microsome (IgG-anti-TM) positivity. Atopy predicted a favorable omalizumab response. Omalizumab response rates were superior in extrinsic (97.2%) and intrinsic (95.1%) groups versus nonatopic (77.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). Nonatopic patients experienced faster symptom relief (28.6% \u226424 hours vs 9.7\u201320.5%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.012). Adverse events were more frequent in atopic subgroups (18.9\u201322.0% vs 4.8%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.020). Low total IgE (&lt;40 IU\/mL) correlated with reduced group responses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Both extrinsic and intrinsic atopy predict better omalizumab responses in CSU. Intrinsic atopic CSU, often neglected, requires further study for personalized approaches. Comprehensive atopy evaluation improves therapeutic stratification in CSU.\n                  <\/jats:p>","DOI":"10.1089\/derm.2025.0089","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T13:00:01Z","timestamp":1747832401000},"page":"649-657","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Both Extrinsic and Intrinsic Atopy in Chronic Spontaneous Urticaria Patients Indicate a Favorable Response to Omalizumab Treatment"],"prefix":"10.1177","volume":"37","author":[{"given":"Anqi","family":"Chen","sequence":"first","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjie","family":"Yang","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifei","family":"Li","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Huang","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Deng","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Huan","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwang","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-4938","authenticated-orcid":false,"given":"Zhiqiang","family":"Song","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-4006","authenticated-orcid":false,"given":"Qiquan","family":"Chen","sequence":"additional","affiliation":[{"name":"From the,  Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 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