{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T10:43:22Z","timestamp":1786185802282,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Treatment with anti-interleukin (IL)-13 antibody lebrikizumab is sometimes associated with the occurrence of conjunctivitis in patients with atopic dermatitis (AD). However, predictive factors for its occurrence are unknown.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To identify predictive factors for the occurrence of conjunctivitis during lebrikizumab treatment for AD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    A prospective study was conducted in 140 Japanese patients with moderate-to-severe AD who received lebrikizumab 500 mg at weeks 0 and 2, followed by 250 mg every 2 weeks until week 16, thereafter every 4 weeks for median 24 (ranging 12\u201336) weeks. We compared baseline clinical and laboratory indices, and background factors between patients who developed conjunctivitis and those who did not.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Conjunctivitis occurred in 20 patients (14.3%) during lebrikizumab treatment. Patients with conjunctivitis had significantly higher immunoglobulin E (IgE) and thymus and activation-regulated chemokine (TARC) compared to those without. Logistic regression analysis showed that the occurrence of conjunctivitis was associated with higher IgE (odds ratio [OR]: 1, 95% confidence interval [CI]: 1.0\u20131.0,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.0287) and TARC (OR: 1, 95% CI: 1.0\u20131.0,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.0441).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Higher IgE and TARC may predict conjunctivitis during lebrikizumab treatment for AD.\n                  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