{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:52:48Z","timestamp":1777557168168,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pathological displacement of teeth caused by periodontitis-related bone loss in patients with diabetes is often corrected with orthodontic treatments. However, recovery from orthodontic therapy is often delayed for unclear reasons. This study explored effects of streptozotocin-induced diabetes in rats on protein expression involved in remodeling of the periodontal ligament (PDL) and alveolar bone during orthodontic tooth movement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Forty-eight Sprague-Dawley rats were randomly divided into two experimental groups: \u201cnormal\u201d and \u201cdiabetes\u201d (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200924 each). Diabetes was induced by a single dose of streptozotocin (65\u2009mg\/kg). Animals were euthanized at 3, 7, and 14 days after orthodontic induction. Changes in expression of collagen type I (Col-I), matrix metalloproteinase type 1 (MMP-1), and tissue inhibitor of MMP-1 (TIMP-1) were measured immunohistochemically in the pressure side. Col-I and collagen type III (Col-III) fibers were assessed by picrosirius red staining in the tension side. Osteoclasts were observed on the surface of the alveolar bone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Diabetes increased expression of MMP-1 and Col-III and decreased expression of Col-I in PDL. After the orthodontic induction, osteoclast action was delayed, and higher Col-III\/Col-I and MMP-1\/TIMP-1 ratios persisted in the diabetes group compared with the normal group. The ratio of MMP-1\/TIMP-1 in the diabetes group reached a peak on Day 7, whereas the ratio remained at near control levels in the normal group. The diabetes group appeared to have worse recovery from damage caused by orthodontic movement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Under mechanical forces, diabetes prolonged duration of degradation of PDL and remodeling of PDL and resorption of alveolar bone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2009.0085","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T13:11:18Z","timestamp":1263820278000},"page":"65-73","source":"Crossref","is-referenced-by-count":27,"title":["Periodontal Ligament Remodeling and Alveolar Bone Resorption During Orthodontic Tooth Movement in Rats with Diabetes"],"prefix":"10.1177","volume":"12","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Feng","sequence":"additional","affiliation":[{"name":"The First Clinical Hospital of Zhejiang Chinese Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangjia","family":"Bi","sequence":"additional","affiliation":[{"name":"Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"81","article-title":"The rising global burden of diabetes and its complications: estimates and projections to the year 2010","volume":"5","author":"Amos AF","year":"1997","unstructured":"Amos AF, , McCarty DJ, , Zimmet P. 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