{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:53:10Z","timestamp":1777557190395,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study looked at the association of cystatin-C (cys-C) with severity of metabolic syndrome in Asian Indians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Five sets of normal glucose tolerance subjects were recruited from the Chennai Urban Rural Epidemiology Study (CURES), a population-based study in southern India: 43 subjects with no metabolic risk factors, 44 subjects with one metabolic risk factor, 37 subjects with two risk factors, 40 subjects with three risk factors, and 40 subjects with four or five metabolic risk factors. Metabolic syndrome was defined using National Cholesterol Education Program criteria for adults modified for waist measured using the World Health Organization Asia Pacific guidelines. Serum cys-C was estimated by a high-sensitivity particle-enhancing nephelometry assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Subjects with four or five metabolic abnormalities had the highest cys-C levels, and with decreasing number of metabolic abnormalities, the cys-C levels decreased linearly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for trend &lt;\u20090.001). Regression analysis showed a linear increase in cys-C levels with increasing number of metabolic abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cys-C levels are highly correlated with the number of metabolic abnormalities in Asian Indians.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2010.0077","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T08:02:17Z","timestamp":1285833737000},"page":"907-912","source":"Crossref","is-referenced-by-count":27,"title":["Association of Cystatin-C with Metabolic Syndrome in Normal Glucose-Tolerant Subjects (CURES-97)"],"prefix":"10.1177","volume":"12","author":[{"given":"Jatagopi","family":"Surendar","sequence":"first","affiliation":[{"name":"Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Indulekha","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Aravindhan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anbazaghan","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwanathan","family":"Mohan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.657627"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1883"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.10.2444"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.03.033"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.658"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-4564.2007.07392.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80804-C"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0084"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7709"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.1895"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0539"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.08.016"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043161"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050545"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.041889"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.061"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145166.44942.E0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.489625"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0471-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.01.040"},{"key":"e_1_3_3_22_2","first-page":"CR97","article-title":"The evaluation of serum cystatin C, malondialdehyde, and total antioxidant status in patients with metabolic syndrome","volume":"14","author":"Demircan N","year":"2008","unstructured":"Demircan N, , Gurel A, , Armutcu F, , Unalacak M, , Aktunc E, , Atmaca H. The evaluation of serum cystatin C, malondialdehyde, and total antioxidant status in patients with metabolic syndrome. Med Sci Monit, 2008; 14:CR97\u2013CR101.","journal-title":"Med Sci Monit"},{"key":"e_1_3_3_23_2","first-page":"242","volume-title":"Mohan V, Rao GHR, eds","author":"Deepa R","year":"2006","unstructured":"Deepa R, , Gokulakrishnan K, , Mohan V. Coronary artery disease among Indian diabetic subjects. Mohan V, Rao GHR, eds. Type 2 Diabetes in South Asians: Epidemiology, Risk Factors and Prevention. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd., 2006; 242\u2013255."},{"key":"e_1_3_3_24_2","first-page":"863","article-title":"The Chennai Urban Rural Epidemiology Study (CURES)\u2014study design and methodology (urban component) (CURES-I)","volume":"51","author":"Deepa M","year":"2003","unstructured":"Deepa M, , Pradeepa R, , Rema M, , Mohan A, , Deepa R, , Shanthirani S, , Mohan V. The Chennai Urban Rural Epidemiology Study (CURES)\u2014study design and methodology (urban component) (CURES-I) J Assoc Physicians India, 2003; 51:863\u2013870.","journal-title":"J Assoc Physicians India"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1962"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2554"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.908.399"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_3_3_29_2","first-page":"17","volume-title":"International Association for the Study of Obesity; International Obesity Task Force: The Asia Pacific Perspective: Redefining Obesity and Its Treatment","author":"World Health Organization Western Pacific Region World Health Organization","year":"2000","unstructured":"World Health Organization Western Pacific Region World Health Organization. International Association for the Study of Obesity; International Obesity Task Force: The Asia Pacific Perspective: Redefining Obesity and Its Treatment. Sydney: Health Communications Australia Pty Ltd., 2000; 17\u201321."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0040"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.06.017"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00406-2"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00517.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.01.003"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.96"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.07.060"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915809"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(90)90272-C"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/joneph\/22.1.29"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145166.44942.E0"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.807271"},{"key":"e_1_3_3_43_2","first-page":"2820","article-title":"Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound","volume":"122","author":"Gu FF","year":"2009","unstructured":"Gu FF, , L\u00fc SZ, , Chen YD, , Zhou YJ, , Song XT, , Jin ZN, , Liu H. Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound. Chin Med J (Engl), 2009; 122:2820\u20132826.","journal-title":"Chin Med J (Engl)"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dia.2010.0077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2010.0077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2010.0077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:17:11Z","timestamp":1777400231000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dia.2010.0077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1089\/dia.2010.0077"],"URL":"https:\/\/doi.org\/10.1089\/dia.2010.0077","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}