{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:03:53Z","timestamp":1777557833868,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>After approval of sitagliptin and &gt;750\u2009mg of metformin in Japan, a triple oral antidiabetes drug (OAD) regimen including sulfonylurea, metformin, and sitagliptin was sometimes described. However, in the real world of clinical practice, the daily dose of sulfonylurea tended to be decreased according to the warning from the Japan Diabetes Society for avoiding hypoglycemia, instead of increasing the dose of metformin for maintaining hemoglobin A1c (HbA1c) levels with this regimen. This study examined the impact of either a small dose of glimepiride or a high dose of metformin on HbA1c in triple OAD therapy with sitagliptin in a 3-month, single-center, open-label, randomized controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>\n                      Fifty-six type 2 diabetes mellitus patients who had been treated with 50\u2009mg of sitagliptin, \u22651,000\u2009mg of metformin, and \u22641\u2009mg of glimepiride with an HbA1c level of &lt;7.4% during at least 3 months were enrolled in the study. The patients were randomly assigned to two treatment groups who either received a 50% reduced dose of metformin (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =27) or discontinued glimepiride (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =29), while sitagliptin administration continued in both groups. Twenty-six patients from the reduced metformin group and 27 patients from the discontinued glimepiride group completed the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Significantly greater changes were observed in HbA1c and glycated albumin levels in patients who discontinued glimepiride than in patients with a 50% reduced metformin dose, during the 2\u20133-month period than in the 1\u20133-month period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Glimepiride is important for good glycemic control in triple OAD therapy with sitaglitpin and metformin. This regimen may be useful for those patients who do not achieve satisfactory glycemic control with dual combination therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2012.0287","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T10:12:10Z","timestamp":1363083130000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Glimepiride Strongly Enhances the Glucose-Lowering Effect in Triple Oral Antidiabetes Therapy with Sitagliptin and Metformin for Japanese Patients with Type 2 Diabetes Mellitus"],"prefix":"10.1177","volume":"15","author":[{"given":"Keiko","family":"Arai","sequence":"first","affiliation":[{"name":"Arai Clinic","place":["Japan"]},{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Maeda","sequence":"additional","affiliation":[{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin-ichiro","family":"Sirabe","sequence":"additional","affiliation":[{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuyuki","family":"Hirao","sequence":"additional","affiliation":[{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Hirao","sequence":"additional","affiliation":[{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hirao","sequence":"additional","affiliation":[{"name":"Health Education Center Science Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_3_2_3_2","first-page":"42","volume-title":"Japan Diabetes Society","author":"Araki E","year":"2007","unstructured":"Araki E, , Yasuhiko I, , Kadowaki T, , Kashiwagi A, , Kitaoka M, , Nanjyo K, , Tajima N. 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J Natl Med Assoc, 2003; 95:774, 779\u2013789.","journal-title":"J Natl Med Assoc"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-366"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0703"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0706"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0627"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2007.00744.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.10.011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2011.35.4.411"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4137\/JCM.S8571"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(01)00365-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-010-0006-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-279"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-399"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(79)90146-X"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1937-z"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.184"},{"key":"e_1_3_2_22_2","first-page":"835","article-title":"Glimepiride (0.5\u2009mg\/day) administration improves glycemic control without weight gain in Japanese type 2 diabetic patients","volume":"50","author":"Urakaze M","year":"2007","unstructured":"Urakaze M, , Yamazaki K, , Usui I, , Iwata M, , Uno T, , Murakami A, , Yamamoto U, , Kishida M, , Aikawa H, , Kawahara J, , Senda S, , Ishizuka K, , Ikemoto M, , Sawazaki S, , Fukui K, , Takano A, , Yamazaki Y, , Hori H, , Wada O, , Kamura Y, , Igarashi Y, , Sato A, , Fukushima H, , Takata M, , Temaru R, , Ohgaku S, , Akagawa N, , Kato H, , Kobayashi M. Glimepiride (0.5\u2009mg\/day) administration improves glycemic control without weight gain in Japanese type 2 diabetic patients. 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