{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:37:55Z","timestamp":1778719075148,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      This study assessed the relationship between the serum level of 1,5-anhydroglucitol (1,5-AG), a marker of postprandial hyperglycemia, and the ratio of the urinary activity of\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      -acetyl-\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      -\n                      <jats:sc>d<\/jats:sc>\n                      -glucosaminidase (NAG) to creatinine (NAG index) in patients with type 2 diabetes mellitus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                      This was a cross-sectional study with 153 patients who had an estimated glomerular filtration rate of \u226560\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      and no proteinuria and who had never been treated with oral hypoglycemic agents or insulin. On the basis of 1,5-AG levels, the patients were divided into a High 1,5-AG group (&gt;14.0\n                      <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                      g\/mL) and a Low 1,5-AG group (\u226414.0\n                      <jats:italic toggle=\"yes\">\u03bc<\/jats:italic>\n                      g\/mL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The logarithmically transformed NAG index was significantly higher in the Low 1,5-AG group than in the High 1,5-AG group when all glycated hemoglobin (HbA1c) levels were included. The logarithmically transformed NAG index was lowest in the High 1,5-AG group with an HbA1c level of \u22646.4% and was highest in the Low 1,5-AG group with an HbA1c level of \u22657.5%. Multivariate regression analysis showed that the NAG index had a higher independent association with 1,5-AG than with HbA1c or the fasting plasma glucose level. In all models, multivariate regression analyses showed that the NAG index was correlated with age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results suggest that postprandial hyperglycemia correlates with early renal tubule injury in type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2013.0155","type":"journal-article","created":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T14:45:47Z","timestamp":1381416347000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Postprandial Glycemic Control Conditions in Relation to Urinary\n                    <i>N<\/i>\n                    -Acetyl-\n                    <i>\u03b2<\/i>\n                    -\n                    <scp>d<\/scp>\n                    -Glucosaminidase in Patients with Type 2 Diabetes Mellitus Without Low Glomerular Filtration Rate"],"prefix":"10.1177","volume":"16","author":[{"given":"Motoshi","family":"Ouchi","sequence":"first","affiliation":[{"name":"Nippon Medical School","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Oba","sequence":"additional","affiliation":[{"name":"Nippon Medical School","place":["Japan"]},{"name":"Oarai Sea Shore Core Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Motoyama","sequence":"additional","affiliation":[{"name":"Nippon Medical School","place":["Japan"]},{"name":"Oarai Sea Shore Core Clinic","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misako","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Nippon Medical 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