{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:04:08Z","timestamp":1790096648679,"version":"4.0.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study examined the association in a South Indian population with gestational diabetes mellitus (GDM) of type 2 diabetes risk variants that have previously conferred susceptibility to GDM in other populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>The study groups comprised 518 women with GDM and 910 pregnant women with normal glucose tolerance (NGT). Women with GDM were recruited from a tertiary diabetes center in Chennai, in south India, and NGT women were selected from antenatal clinics also in Chennai. Genomic DNA was isolated from whole blood using the phenol chloroform method. Twelve previously reported GDM-associated single nucleotide polymorphisms (SNPs) in or near nine loci were genotyped using the MassARRAY\u2122 system (Sequenom, San Diego, CA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 12 SNPs genotyped, 11 SNPs were in Hardy\u2013Weinberg equilibrium and had a call rate of &gt;95%. Of the 11 SNPs previously associated with GDM in other populations, significant association was observed only with the rs7754840 and rs7756992 SNPs of the\n                      <jats:italic toggle=\"yes\">CDK5 regulatory subunit associated protein 1-like 1<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">CDKAL1<\/jats:italic>\n                      ) gene in this population. The minor alleles of the SNPs rs7754840 and rs7756992 showed significant susceptibility to GDM with an odds ratio of 1.34 (95% confidence interval, 1.12\u20131.60;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0013) and 1.45 (95% confidence interval, 1.21\u20131.72;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.00004), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The rs7754840 and rs7756992 SNPs of the\n                      <jats:italic toggle=\"yes\">CDKAL1<\/jats:italic>\n                      gene were found to be associated with GDM in this south Indian population. This is the first study describing genetic susceptibility of GDM in Asian Indians.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2014.0349","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T15:37:12Z","timestamp":1425051432000},"page":"462-467","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Identification of Genetic Variants of Gestational Diabetes in South Indians"],"prefix":"10.1177","volume":"17","author":[{"given":"Sekar","family":"Kanthimathi","sequence":"first","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manickam","family":"Chidambaram","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Liju","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Bhavadharini","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanasekaran","family":"Bodhini","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visvanathan Gnana","family":"Prakash","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandakumar","family":"Amutha","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruyerchelvan","family":"Bhavatharini","sequence":"additional","affiliation":[{"name":"SRC Diabetes Care Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit Mohan","family":"Anjana","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]},{"name":"IDF Centre of Education","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanathan","family":"Mohan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]},{"name":"IDF Centre of Education","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesan","family":"Radha","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524531"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780059643"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2011.35.1.1"},{"key":"e_1_3_3_5_2","first-page":"1","article-title":"An analysis of targeted single nucleotide polymorphisms for the risk prediction of gestational diabetes mellitus in a cohort of Malaysian patients","volume":"1","author":"Aris NKM","year":"2011","unstructured":"Aris NKM, , Ismail NAM, , Mahdy ZA, et al.: An analysis of targeted single nucleotide polymorphisms for the risk prediction of gestational diabetes mellitus in a cohort of Malaysian patients. 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