{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:46:13Z","timestamp":1777556773887,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Only a few studies have reported the use of oral antidiabetes drugs (OADs) for treating older adults with type 2 diabetes mellitus (T2DM) in China. This study assessed the status of OAD therapy and relevant factors associated with OAD treatment patterns and glycemic control among older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>We conducted a noninterventional, observational, cross-sectional, multicenter study, which was initiated by the Chinese Diabetes Society, in which 9,872 outpatients with T2DM were recruited who received OADs only. Current antidiabetes treatment regimens and related clinical data were collected from patients' self-reporting and medical records. Participants were divided into two groups: \u226565 years and &lt;65 years. All data were tabulated, and statistical analyses were performed using SPSS version 16 software (SPSS Inc., Chicago, IL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Insulin secretagogues (52.6%): sulfonylureas (SU) (26.6%) and glinides (26.0%) were commonly used as monotherapy in those \u226565 years. The most popular OAD pattern was dual combination therapy (46.8%), with SU plus glucosidase inhibitors (25.1%) being most common in older participants. Age, diabetes duration, body mass index, achieving the glycemic control targets, and hypoglycemia were influencing factors to those \u226565 years in diverse treatment pattern models (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Older patients receiving OADs with triple or more combination treatment and complications were more likely to have substandard glycemic control (hemoglobin A1c level \u22657%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The pattern of OADs alone in older adults with T2DM was significantly different from those &lt;65 years in China. A comprehensive OAD treatment pattern or insulin combination may be necessary for better glycemic control in older patients with multiple combinations of OADs or complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2015.0094","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T15:37:47Z","timestamp":1444318667000},"page":"816-824","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Treatment Patterns and Glycemic Control in Older Adults with Type 2 Diabetes Mellitus Receiving Only Oral Antidiabetes Drugs in China"],"prefix":"10.1177","volume":"17","author":[{"given":"Lihua","family":"Zhang","sequence":"first","affiliation":[{"name":"Peking University People's Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linong","family":"Ji","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juming","family":"Lu","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoming","family":"Tian","sequence":"additional","affiliation":[{"name":"Sichuan University West China Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Xing","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian Ping","family":"Weng","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University Affiliated Sixth People's Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the China Type 2 Diabetes Treatment Status Survey of Treatment Pattern of Oral Drugs Users (China DiaSTAGE) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908292"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.168118"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.726"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-6047.2001.00211.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67344-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.27.4.1064"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1046\/j.1532-5415.51.5s.1.x","article-title":"Guidelines for improving the care of the older person with diabetes mellitus","volume":"51","author":"Brown AF","year":"2003","unstructured":"Brown AF, , Mangione CM, , Saliba D, et al.: Guidelines for improving the care of the older person with diabetes mellitus. 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Chin Med J (Engl), 2011; 124:2461\u20132468.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12165"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.12956"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.02.003"},{"key":"e_1_3_3_17_2","unstructured":"Chinese Diabetes Society: 2013 China Guidelines for Type 2 Diabetes. Beijing: Peking University Medical Press 2014:16\u201318."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2361"},{"key":"e_1_3_3_19_2","unstructured":"NICE: The Management of Type 2 Diabetes 2010 NICE Guidelines. May 2009. 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