{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:33:03Z","timestamp":1790249583320,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 (GLP-1) is a powerful insulin secretagogue that is secreted in response to meal ingestion. The ability to quantify the effect of GLP-1 on insulin secretion could provide insights into the pathogenesis and treatment of diabetes. We used a modification of a model of GLP-1 action on insulin secretion using data from a hyperglycemic clamp with concomitant GLP-1 infusion. We tested this model using data from a mixed meal test (MMT), thereby measuring GLP-1-induced potentiation of insulin secretion in response to a meal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The GLP-1 model is based on the oral C-peptide minimal model and assumes that over-basal insulin secretion depends linearly on GLP-1 concentration through the parameter \u03a0, representing the \u03b2-cell sensitivity to GLP-1. The model was tested on 62 subjects across the spectrum of glucose tolerance (age, 53\u2009\u00b1\u20091 years; body mass index, 29.7\u2009\u00b1\u20090.6\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) studied with an MMT and provided a precise estimate of both \u03b2-cell responsivity and \u03a0 indices. By combining \u03a0 with a measure of L-cell responsivity to glucose, one obtains a potentiation index (PI) (i.e., a measure of the L-cell's function in relation to prevailing \u03b2-cell sensitivity to GLP-1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Model-based measurement of GLP-1-induced insulin secretion demonstrates that the PI is significantly reduced in people with impaired glucose tolerance, compared with those with normal glucose tolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We describe a model that can quantitate the GLP-1-based contribution to insulin secretion in response to meal ingestion. This methodology will allow a better understanding of \u03b2-cell function at various stages of glucose tolerance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2015.0146","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T20:57:48Z","timestamp":1452632268000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Model-Based Quantification of Glucagon-Like Peptide-1\u2013Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge"],"prefix":"10.1177","volume":"18","author":[{"given":"Chiara","family":"Dalla Man","sequence":"first","affiliation":[{"name":"University of Padua","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Micheletto","sequence":"additional","affiliation":[{"name":"University of Padua","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheni","family":"Sathananthan","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Vella","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cobelli","sequence":"additional","affiliation":[{"name":"University of Padua","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.054"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69705-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.07.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb17549.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.6.0385"},{"key":"e_1_3_3_7_2","first-page":"461","article-title":"Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism","volume":"6","author":"Vahl T","year":"2003","unstructured":"Vahl T, , D'Alessio D: Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism. 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