{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:06:56Z","timestamp":1779433616682,"version":"3.53.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Research is still going on for detecting the earliest glucose homeostasis derangements in individuals, which is crucial for the prevention of glucose intolerance. This cross-sectional study analyzes different insulin response patterns during the oral glucose tolerance test (OGTT) and their implications on glycemia in normoglycemic individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>The sample frame was the \u201cOffspring of Individuals with Diabetes Study\u201d database. All participants underwent OGTT. Blood samples were collected at 0, 30, 60, and 120\u2009min for measurement of insulin, C-peptide, and proinsulin levels. Normal glucose tolerant individuals were selected for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Four hundred fifty subjects (mean age, 25 years) were included and divided into two groups according to timing of plasma insulin peaking during OGTT: Group 1, peaking at 30\u2009min; and Group 2, peaking at 60 or 120\u2009min. Body mass index (BMI) and insulin resistance were comparable between the groups; however, Group 2 showed a significantly higher 60- and 120-min glucose level and lower disposition index. Based on the magnitude of the insulin levels, Group 1 was subdivided into Group N (normal pattern) and Group E (exaggerated pattern) with a 30-min insulin cutoff of 74\u2009\u03bcU\/mL (Group E, \u226574\u2009\u03bcU\/mL). Group 2 was subdivided into Group DL (delayed and limited pattern; 60-min insulin &lt;73.0\u2009\u03bcU\/mL and 120-min insulin &lt;80.0\u2009\u03bcU\/mL) and Group DE (delayed and exaggerated pattern; 60-min insulin \u226573.0\u2009\u03bcU\/mL or 120-min insulin \u226580.0\u2009\u03bcU\/mL). Group DE showed a significantly higher area under the curve (AUC) of glucose compared with the other groups and had a lower disposition index and high-density lipoprotein levels. Group DL had significantly lower insulin resistance and BMI compared with Group E but showed a similar AUC of glucose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A delayed insulin pattern was associated with higher postprandial glucose levels. Individuals with delayed and exaggerated insulin secretion may have a higher risk for glucose intolerance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2015.0379","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T12:24:27Z","timestamp":1455711867000},"page":"316-326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Different Insulin Response Patterns During Oral Glucose Tolerance Test on Glycemia in Individuals with Normal Glucose Tolerance"],"prefix":"10.1177","volume":"18","author":[{"given":"Edavan Pulikkanath","family":"Praveen","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Chouhan","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaprakash","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru Institute of Postgraduate Medical Education and Research","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir K.","family":"Goel","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sada Nand","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madan Lal","family":"Khurana","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Kulshreshtha","sequence":"additional","affiliation":[{"name":"Ram Manohar Lohia Hospital","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariachery C.","family":"Ammini","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1381-z"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610030204"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.32.7.675"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2179"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1200"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.868"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.595"},{"key":"e_1_3_3_9_2","first-page":"842","article-title":"Patterns of insulin secretion in man","volume":"67","author":"Jarret RJ","year":"1974","unstructured":"Jarret RJ: Patterns of insulin secretion in man. 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