{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:31:24Z","timestamp":1777555884611,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The current life expectancy in India is &lt;70 years. Type 2 diabetes mellitus (T2DM) is known to reduce life expectancy by 6\u20138 years. Hence elderly people with T2DM in India would be rare. We report on the clinical profile of Asian Indian patients with T2DM who lived beyond 90 years of age and compared them with T2DM patients aged 50 to 60 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From the diabetes electronic medical records of &gt;470,000 diabetes patients, we identified T2DM patients who had lived \u226590 years and compared them with those in the 50\u201360 years age group, matched for gender and duration of diabetes. Clinical data included age at last visit, age at diagnosis, duration of diabetes, family history, smoking and alcohol, details of medications, body mass index (BMI), and blood pressure. Biochemical data included fasting and postprandial plasma glucose, glycated hemoglobin, fasting and stimulated C-peptide levels, lipid profile, and renal function studies. Assessment of retinopathy, nephropathy, neuropathy, coronary artery disease (CAD), and peripheral vascular disease (PVD) was also done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 325 T2DM patients aged \u226590 years and 278 T2DM patients aged between 50 and 60 years were selected for the study. Patients aged \u226590 years had higher systolic blood pressure (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lower BMI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) than those between 50 and 60 years. Prevalence of retinopathy (29.7% vs. 53.5%) and macroalbuminuria (3.7% vs. 16.0%) was lower in the \u226590 years T2DM patients than in the 50\u201360 years age group. However, prevalence of neuropathy (89.8% vs. 50.8%), PVD (13.5% vs. 2.0%), and CAD (60.3% vs. 32.0%) was higher among the \u226590 years patients. Eighty-five percent of the T2DM aged \u226590 years were on oral hypoglycemic agents (OHAs), (of whom 64.9% were on sulfonylurea), 12% were on insulin, and 3% on diet alone. Among the 50\u201360 years old, 87.8% were on OHAs and 12.2% on insulin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first report on the clinical profile of Asian Indians with T2DM aged \u226590 years, and significant differences are seen in their clinical profile compared with younger T2DM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2019.0219","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T10:29:35Z","timestamp":1571740175000},"page":"79-84","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Profile of Elderly Patients (Over 90 Years) with Type 2 Diabetes Seen at a Diabetes Center in South India"],"prefix":"10.1177","volume":"22","author":[{"given":"Mohan","family":"Viswanathan","sequence":"first","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."},{"name":"Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjana","family":"Ranjit Mohan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."},{"name":"Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unnikrishnan","family":"Ranjit","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."},{"name":"Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gupta","family":"Prasanna Kumar","sequence":"additional","affiliation":[{"name":"Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Routary","family":"Philips","sequence":"additional","affiliation":[{"name":"Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jebarani","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesan","family":"Ulagamathesan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma Sankari","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gini Venisha","family":"Kumaradas","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok Kumar","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahulashankiruthiyayan","family":"Thangarajan","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeepa","family":"Rajendra","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanthi Rani","family":"Coimbatore Subramanian","sequence":"additional","affiliation":[{"name":"Madras Diabetes Research Foundation, ICMR Center for Advanced Research on Diabetes, Chennai, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"47","article-title":"Ageing, activities of daily living disabilities and the need for public health initiatives: some evidence from a household survey in India","volume":"20","author":"Alam M","year":"2005","unstructured":"Alam M, , Mukherjee M: Ageing, activities of daily living disabilities and the need for public health initiatives: some evidence from a household survey in India. Asia Pac Popul J, 2005; 20:47\u201376.","journal-title":"Asia Pac Popul J"},{"key":"e_1_3_5_3_2","first-page":"1","article-title":"\u201cAgeing in India.\u201d","volume":"2","author":"Irudaya Rajan S","year":"2000","unstructured":"Irudaya Rajan S, , Mishra US, , Sarma PS: \u201cAgeing in India.\u201d. Indian Soc Sci Rev, 2000; 2:1\u201348.","journal-title":"Indian Soc Sci Rev"},{"key":"e_1_3_5_4_2","unstructured":"National Sample Survey Organization. \u201cSocio-economic profile of the aged persons \u201d NSS 52nd round July 1995\u2013June 1996 (Report No. 446). New Delhi: Government of India 1998."},{"key":"e_1_3_5_5_2","unstructured":"United Nations Department of Economic and Social Affairs Population Division. World Population Ageing 2015 (ST\/ESA\/SER.A\/390). 2015. https:\/\/www.un.org\/en\/development\/desa\/population\/publications\/pdf\/ageing\/WPA2015_Report.pdf (accessed June5 2019)."},{"key":"e_1_3_5_6_2","unstructured":"Population projections. http:\/\/censusindia.gov.in\/2011-prov-results\/data_files\/india\/Final_PPT_2011_chapter8.pdf (accessed June5 2019)."},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7008"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.06.012"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03836.x"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49180.x"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30051-2"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_3_5_13_2","first-page":"409","article-title":"Glycaemic and insulin responses to some breakfast items in diabetic subjects","volume":"37","author":"Viswanathan M","year":"1988","unstructured":"Viswanathan M, , Snehalatha C, , Ramachandran A, et al.: Glycaemic and insulin responses to some breakfast items in diabetic subjects. Nutr Rep Int, 1988; 37:409\u2013418.","journal-title":"Nutr Rep Int"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2011.04.003"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0019"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2554"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02397.x"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.9.1295"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01415-2"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.4103\/0189-7969.142094"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.5455\/ijmsph.2016.0105201576"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.11.1936"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2010.06.017"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.19.4.172"},{"key":"e_1_3_5_28_2","first-page":"70","article-title":"Diabetes care for older adults","volume":"12","author":"Mooradian AD","year":"1999","unstructured":"Mooradian AD, , McLaughlin S, , Boyer CC, et al.: Diabetes care for older adults. Diabetes Spectrum, 1999; 12:70\u201377.","journal-title":"Diabetes Spectrum"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S348"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2015.0094"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1296"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1193"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229681100500309"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.13772"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dia.2019.0219","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2019.0219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2019.0219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:12:31Z","timestamp":1777399951000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dia.2019.0219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,22]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1089\/dia.2019.0219"],"URL":"https:\/\/doi.org\/10.1089\/dia.2019.0219","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,22]]}}}