{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:24:29Z","timestamp":1787167469134,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    In the past few years, the increasing use of devices for diabetes treatment, such as continuous subcutaneous insulin infusion pumps, flash glucose monitoring, continuous glucose monitoring systems, sensor-augmented pumps, and automated insulin delivery devices, has resulted in important improvements in disease management. Meanwhile, the longer a patient uses a device, the greater the likelihood of developing a skin reaction. Allergic contact dermatitis is the most frequently described skin side effect caused by adhesive tapes contained in the insulin infusion sets or glucose sensor sets and used to connect these devices to the body. We describe 18 patients, followed up at our Pediatric Diabetes Centre, who experienced dermatological complications due to diabetes device use from January 2018 to December 2018. All the patients were patch tested with allergens from a \u201cstandard\u201d series and from a \u201cplastics and glues\u201d series. Patch tests resulted positive in 66.7% of patients. Colophonium was the most frequently isolated sensitizing allergen (41.1% of cases). It is a complex mixture of\n                    <jats:italic toggle=\"yes\">&gt;<\/jats:italic>\n                    100 compounds derived from pine trees. Colophonium is commonly used, in both unmodified and modified forms, as a fast-acting adhesive for industrial, medical, or other commercial uses. Its presence in the adhesive of the insulin sets and glucose sensors was confirmed by the manufacturer of some devices brand. On the basis of our results, we stress the importance of contacting manufacturers for product information. We also highlight that there should be stricter legal restrictions to label medical adhesives, even if only small amounts of colophonium are used.\n                  <\/jats:p>","DOI":"10.1089\/dia.2019.0236","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T10:05:51Z","timestamp":1567073151000},"page":"53-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["High Prevalence of Skin Reactions Among Pediatric Patients with Type 1 Diabetes Using New Technologies: The Alarming Role of Colophonium"],"prefix":"10.1177","volume":"22","author":[{"given":"Fortunato","family":"Lombardo","sequence":"first","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Passanisi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Allergy Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barbalace","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Iannelli","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Pajno","sequence":"additional","affiliation":[{"name":"Allergy Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Salzano","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi,\u201d University of Messina, Messina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2016.1115013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2653"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12652"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2015.0417"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296815603528"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1248"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2584"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12995"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13017"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13012"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12503"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12873"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000281"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2016.08.014"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1139"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13337"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13089"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0007"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0088"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0080"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13120"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12144"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12170"},{"key":"e_1_3_3_25_2","first-page":"1","article-title":"Regulation (EC) No. 1272\/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67\/548\/EEC and 1999\/45\/EC, and amending Regulation (EC) No. 1907\/2006","volume":"135","author":"The European Parliament and the Council of the European Union","year":"2008","unstructured":"The European Parliament and the Council of the European Union: Regulation (EC) No. 1272\/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67\/548\/EEC and 1999\/45\/EC, and amending Regulation (EC) No. 1907\/2006. Off J Eur Union, 2008; L135:1\u20131355.","journal-title":"Off J Eur Union"},{"key":"e_1_3_3_26_2","first-page":"1","article-title":"Council Directive 93\/42\/EEC of 14 June 1993 concerning medical devices","volume":"169","author":"The European Parliament and the Council of the European Union","year":"1993","unstructured":"The European Parliament and the Council of the European Union: Council Directive 93\/42\/EEC of 14 June 1993 concerning medical devices. Off J Eur Union, 1993; L169:1\u201343.","journal-title":"Off J Eur Union"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dia.2019.0236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2019.0236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2019.0236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:18:46Z","timestamp":1777400326000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dia.2019.0236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1089\/dia.2019.0236"],"URL":"https:\/\/doi.org\/10.1089\/dia.2019.0236","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}