{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:08:29Z","timestamp":1790201309922,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology & Therapeutics"],"published-print":{"date-parts":[[2020,9]]},"abstract":"\n Insulclock<\/jats:italic>\n \u00ae<\/jats:sup>\n is an electronic device designed to improve treatment adherence and insulin injection tracking. This randomized, single-center, pilot study assessed the clinical impact of\n Insulclock<\/jats:italic>\n on glycemic control and variability, treatment adherence, and satisfaction in patients with uncontrolled type 1 diabetes mellitus (T1DM). We also compared these outcomes between the Active and Masked groups (with or without receiving reminders and app alerts). Sixteen patients completed the study: 10 in the Active group and 6 in the Masked group. Insulclock use was associated with a decrease in mean glucose (\u221227.0\u2009mg\/dL [1.5\u2009mmol\/L];\n P<\/jats:italic>\n \u2009=\u20090.013), glucose standard deviation (\u221214.4\u2009mg\/dL [0.8\u2009mmol\/L];\n P<\/jats:italic>\n \u2009=\u20090.003), and time above range (\u221212.5%;\n P<\/jats:italic>\n \u2009=\u20090.0026), and an increase in time in range (TIR) (+7%;\n P<\/jats:italic>\n \u2009=\u20090.038) in the overall population. The use of app information and alerts in the Active group was associated with an increase in TIR (+8%;\n P<\/jats:italic>\n \u2009=\u20090.026). We observed a \u22123.9 (\n P<\/jats:italic>\n \u2009=\u20090.1352) and \u22125.4 (\n P<\/jats:italic>\n \u2009=\u20090.032) reduction per month in the number of missed and mistimed insulin doses in the overall population, respectively. Most of the items of the Insulin Treatment Satisfaction Questionnaire (ITSQ) improved after 4 weeks of\n Insulclock<\/jats:italic>\n use. This pilot study points out an improvement in glycemic levels, adherence, and satisfaction in T1DM patients, supporting the development of clinical trials powered to confirm these effects.\n <\/jats:p>","DOI":"10.1089\/dia.2019.0427","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T16:38:05Z","timestamp":1582043885000},"page":"686-690","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of\n Insulclock<\/i>\n in Patients with Poorly Controlled Type 1 Diabetes Mellitus: A Pilot, Randomized Clinical Trial"],"prefix":"10.1177","volume":"22","author":[{"given":"Fernando","family":"Gomez-Peralta","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Abreu","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gomez-Rodriguez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Cruz-Bravo","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mar\u00eda-Sanchez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Poza","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, Segovia General Hospital, Segovia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ruiz-Valdepe\u00f1as","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Insulcloud S.L. (B87131454), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/db19-2459-PUB"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2014.07.006"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphs.12016"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.09.003"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1218"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296818768618"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13307"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814567708"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0346"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12669"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0361"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0029"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814523881"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90059-8"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208942"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1769"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1088"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1475"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01300-1"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.3.e221"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/db19-126-LB"}],"container-title":["Diabetes Technology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dia.2019.0427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2019.0427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2019.0427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:12:43Z","timestamp":1777399963000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dia.2019.0427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1089\/dia.2019.0427"],"URL":"https:\/\/doi.org\/10.1089\/dia.2019.0427","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}