{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:32:46Z","timestamp":1789471966447,"version":"build-2803163510"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Data are limited on the need for and benefits of pump setting optimization with automated insulin delivery. We examined clinical management of a closed-loop control (CLC) system and its relationship to glycemic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We analyzed personal parameter adjustments in 168 participants in a 6-month multicenter trial of CLC with Control-IQ versus sensor-augmented pump (SAP) therapy. Preset parameters (BR\u2009=\u2009basal rates, CF\u2009=\u2009correction factors, CR\u2009=\u2009carbohydrate ratios) were optimized at randomization, 2 and 13 weeks, for safety issues, participant concerns, or initiation by participants' usual diabetes care team. Time in range (TIR 70\u2013180\u2009mg\/dL) was compared in the week before and after parameter changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In 607 encounters for parameter changes, there were fewer adjustments for CLC than SAP (3.4 vs. 4.1\/participant). Adjustments involved BR (CLC 69%, SAP 80%), CR (CLC 68%, SAP 50%), CF (CLC 44%, SAP 41%), and overnight parameters (CLC 62%, SAP 75%). TIR before and after adjustments was 71.2% and 71.3% for CLC and 61.0% and 62.9% for SAP. The highest baseline HbA\n                      <jats:sub>1c<\/jats:sub>\n                      CLC subgroup had the largest TIR improvement (51.2% vs. 57.7%). When a CR was made more aggressive in the CLC group, postprandial time &gt;180\u2009mg\/dL was 43.1% before the change and 36.0% after the change. The median postprandial time &lt;70\u2009mg\/dL before making CR less aggressive was 1.8%, and after the change was 0.7%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      No difference in TIR was detected with parameter changes overall, but they may have an effect in higher HbA\n                      <jats:sub>1c<\/jats:sub>\n                      subgroups or following user-directed boluses, suggesting that changes may matter more in suboptimal control or during discrete periods of the day.\n                    <\/jats:p>\n                    <jats:p>Clinical Trials Registration number: NCT03563313.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2020.0472","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T10:09:13Z","timestamp":1604657353000},"page":"245-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical Management and Pump Parameter Adjustment of the Control-IQ Closed-Loop Control System: Results from a 6-Month, Multicenter, Randomized Clinical Trial"],"prefix":"10.1177","volume":"23","author":[{"given":"Grenye","family":"O'Malley","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel H.","family":"Messer","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado, Aurora, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol 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