{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:18:23Z","timestamp":1792513103273,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the degree, duration, mean absolute relative difference (MARD), and error analysis of discrepant values per continuous glucose monitoring (CGM) systems after hydroxyurea (HU) administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods:<\/jats:title>\n                    <jats:p>Inpatient glucometer and CGM data from 16 total pancreatectomy\/islet autotransplantation patients using Dexcom Professional G4 and 12 patients using Dexcom G6 were analyzed after daily dosing with HU. Timing of HU dosing and median of 9.5 days of sensor and glucometer values were assessed per patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A large positive elevation of sensor readings was identified after HU dosing. The greatest discrepancy between glucometer and sensor readings occurred 0.5\u20132\u2009h after HU administration [G4 (mean 3.0\u2009mmol\/L, median 2.4\u2009mmol\/L, MARD 55%), G6 (mean 4.2\u2009mmol\/L, median 4.6\u2009mmol\/L, MARD 91%)]. The discrepancy was &lt;1.1\u2009mmol\/L, mean (\u22120.5\u2009mmol\/L) and median (\u22120.5\u2009mmol\/L), MARD 14% (G4) and &lt;1.1\u2009mmol\/L, mean (0.3\u2009mmol\/L) and median (0.3\u2009mmol\/L), MARD 17% (G6), by 6\u2009h after administration. Error analysis with the G6 system found 94% of pairs in clinically acceptable range by 6\u20139\u2009h after HU administration. Aspirin, also given once daily, did not result in glucose value discrepancy with the G6 system but variability was observed with the G4 system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There was marked elevation of sensor glucose readings compared with glucometer values [up to 13.9\u2009mmol\/L (G4), 13\u2009mmol\/L (G6)] from 0.5 to 6\u2009h after HU administration. It is important to counsel a patient using a Dexcom CGM system and HU therapy on this finding and to advise reliance on glucometer testing for accurate glucose assessment up to 6\u20139\u2009h after HU administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2020.0490","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T09:46:34Z","timestamp":1607939194000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Inaccurate Glucose Sensor Values After Hydroxyurea Administration"],"prefix":"10.1177","volume":"23","author":[{"given":"Siobhan E.","family":"Tellez","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey N.","family":"Hornung","sequence":"additional","affiliation":[{"name":"Divisions of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Courter","sequence":"additional","affiliation":[{"name":"Divisions of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Abu-El-Haija","sequence":"additional","affiliation":[{"name":"Divisions of Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie D.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."},{"name":"Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Elder","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.10517"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.09.019"},{"key":"e_1_3_4_4_2","first-page":"507","article-title":"Thrombocytosis in children","volume":"63","author":"Chiarello P","year":"2011","unstructured":"Chiarello P, , Magnolia M, , Rubino M, et al.: Thrombocytosis in children. Minerva Pediatr, 2011; 63:507\u2013513.","journal-title":"Minerva Pediatr"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1759"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000569"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.9.1161"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1095-0"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2014.0061"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12998"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-5-39"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0023"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296816662047"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0150"},{"key":"e_1_3_4_15_2","unstructured":"Dexcom G4\u00ae PLATINUM CGM Enabled. 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