{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:15:05Z","timestamp":1787066105337,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To characterize patients with diabetes treated with a tubeless insulin pump (Omnipod\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Insulin Management System; Insulet Corp., Acton, MA), and to evaluate the frequency of acute complications with long-term use of the system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This retrospective analysis of the German\/Austrian Diabetes Patienten Verlaufsdokumentation (DPV) registry included data from 3657 patients with diabetes (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20093582 type 1,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200925 type 2,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200950 latent autoimmune diabetes in adults\/other) treated with a tubeless insulin pump. Hemoglobin A1c (HbA1c) levels and frequency of diabetic ketoacidosis (DKA) and severe hypoglycemia (SH) were compared between 1 year pre- and 1 year (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092911) or up to 3 years (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091311) post-tubeless insulin pump initiation and compared with a contemporary cohort on multiple daily injections (MDI) with 3-year data (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091874).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients using tubeless insulin pump therapy had a median age of 13.7 years [interquartile range 10.8, 17.3], diabetes duration 3.7 years [1.7, 8.0], and HbA1c 7.5% [6.9, 8.2]. In patients with 3 years of follow-up data (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091311), the percentage with \u22651 episode of DKA, SH (Level 3, requiring assistance), and SH (coma) event with prior treatment was 6.3%, 5.5%, and 1.7%, respectively. After 3 years of tubeless insulin pump therapy, the frequency of DKA, SH (Level 3), and SH (coma) decreased to 2.2%, 4.1%, and 0.5%, respectively. Both DKA and SH remained significantly lower compared with MDI after adjustment in multiple regression analysis. High treatment retention rates (&gt;90%) were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Real-world registry data document that tubeless insulin pump therapy is associated with good glycemic control and a low frequency of DKA and SH in an age group prone to acute complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2020.0675","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T17:27:48Z","timestamp":1615224468000},"page":"527-536","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Declining Frequency of Acute Complications Associated with Tubeless Insulin Pump Use: Data from 2,911 Patients in the German\/Austrian Diabetes Patienten Verlaufsdokumentation Registry"],"prefix":"10.1177","volume":"23","author":[{"given":"Torben","family":"Biester","sequence":"first","affiliation":[{"name":"AUF DER BULT Diabetes Center for Children and Adolescents, Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Schwandt","sequence":"additional","affiliation":[{"name":"Institute for Epidemiology and Medical Biometry,ZIBMT,Ulm University, Ulm, Germany."},{"name":"German Center for Diabetes Research (DZD),Neuherberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Heidtmann","sequence":"additional","affiliation":[{"name":"Catholic Children's Hospital Wilhelmstift,Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Rami-Merhar","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine,Medical University of Vienna, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Haak","sequence":"additional","affiliation":[{"name":"Diabetes Clinic Bad Mergentheim,Bad Mergentheim,Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Festa","sequence":"additional","affiliation":[{"name":"Landesklinikum Korneuburg Stockerau,Korneuburg Stockerau,Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kostow","sequence":"additional","affiliation":[{"name":"Sana Klinikum Lichtenberg\u2014Oskar-Ziethen-Krankenhaus,Berlin,Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Stoffwechsel und Diabetes,Karlsburg,Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"M\u00f6nkem\u00f6ller","sequence":"additional","affiliation":[{"name":"Kinderklinik Amsterdamerstrasse, K\u00f6ln, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Danne","sequence":"additional","affiliation":[{"name":"AUF DER BULT Diabetes Center for Children and Adolescents, Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the DPV Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hungele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bollow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Hadjiyianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Huyett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Layne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Aachen\u2014Innere RWT H,Aachen\u2014Uni-Kinderklinik RWTH,Aalen Kinderklinik, Ahlen St. Franziskus Kinderklinik, Aidlingen Praxisgemeinschaft, Alt\u00f6tting Zentrum Inn-Salzach, Alt\u00f6tting-Burghausen Innere Medizin, Amberg Kinderklinik St. Marien,vAmstetten Klinikum Mostviertel Kinderklinik, Arnsberg-H\u00fcsten Karolinenhosp. 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