{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:35:01Z","timestamp":1777556101034,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hybrid Closed-Loop (HCL) systems aid individuals with type 1 diabetes in improving glycemic control; however, sustained use over time has not been consistent for all users. This study developed and validated prognostic models for successful 12-month use of the first commercial HCL system based on baseline and 1- or 3-month data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>\n                      Data from participants at the Barbara Davis Center (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200985) who began use of the MiniMed 670G HCL were used to develop prognostic models using logistic regression and Lasso model selection. Candidate factors included sex, age, duration of diabetes, baseline hemoglobin A1c (HbA1c), race, ethnicity, insurance status, history of insulin pump and continuous glucose monitor use, 1- or 3-month Auto Mode use, boluses per day, and time in range (TIR; 70\u2013180\u2009mg\/dL), and scores on behavioral questionnaires. Successful use of HCL was predefined as Auto Mode use \u226560%. The 3-month model was then externally validated against a sample from Stanford University (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u200955).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Factors in the final model included baseline HbA1c, sex, ethnicity, 1- or 3-month Auto Mode use, Boluses per Day, and TIR. The 1- and 3-month prognostic models had very good predictive ability with area under the curve values of 0.894 and 0.900, respectively. External validity was acceptable with an area under the curve of 0.717.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our prognostic models use clinically accessible baseline and early device-use factors to identify risk for failure to succeed with 670G HCL technology. These models may be useful to develop targeted interventions to promote success with new technologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2021.0326","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T14:34:46Z","timestamp":1636986886000},"page":"157-166","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Predicting Success with a First-Generation Hybrid Closed-Loop Artificial Pancreas System Among Children, Adolescents, and Young Adults with Type 1 Diabetes: A Model Development and Validation Study"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-9788","authenticated-orcid":false,"given":"Gregory P.","family":"Forlenza","sequence":"first","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Anschutz Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-8570","authenticated-orcid":false,"given":"Tim","family":"Vigers","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Anschutz Campus, Aurora, Colorado, USA."},{"name":"Department of Biostatistics and Informatics, University of Colorado Anschutz Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cari","family":"Berget","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Anschutz Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel H.","family":"Messer","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Anschutz Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8055-944X","authenticated-orcid":false,"given":"Rayhan A.","family":"Lal","sequence":"additional","affiliation":[{"name":"Stanford Diabetes Research Center, School of Medicine, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Basina","sequence":"additional","affiliation":[{"name":"Stanford Diabetes Research Center, School of Medicine, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Maahs","sequence":"additional","affiliation":[{"name":"Stanford Diabetes Research Center, School of Medicine, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-7749","authenticated-orcid":false,"given":"Korey","family":"Hood","sequence":"additional","affiliation":[{"name":"Stanford Diabetes Research Center, School of Medicine, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Buckingham","sequence":"additional","affiliation":[{"name":"Stanford Diabetes Research Center, School of Medicine, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Stanford Diabetes Research Center, School of Medicine, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4139-2122","authenticated-orcid":false,"given":"R. 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