{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:22:24Z","timestamp":1792142544440,"version":"4.4.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated the effect of two key timings for basal insulin rate reduction on exercise-induced glucose changes and explored the association between circulating insulin concentrations and muscle vasoreactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty adults and adolescents performed 60-min exercise sessions (ergocycle) at 60% VO\n                      <jats:sub>2peak<\/jats:sub>\n                      , 240\u2009min after a standardized lunch. In a randomized order, we compared an 80% basal insulin reduction applied 40\u2009min (T-40) or 90\u2009min (T-90) before exercise onset. Near-infrared spectroscopy was used to investigate muscle hemodynamics at vastus lateralis. Glucose and insulin plasma concentrations were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Reduction in plasma glucose (PG) level during exercise was attenuated during T-90 versus T-40 strategy (\u22120.89\u2009\u00b1\u20091.89\u2009mmol\/L vs. \u22122.17\u2009\u00b1\u20092.49\u2009mmol\/L, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.09). Linear mixed model analysis showed that PG dropped by an additional 0.01\u2009mM per minute in T-40 versus T-90 (time\u2009\u00d7\u2009strategy interaction,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The absolute number of hypoglycemic events was not different between the two strategies, but they occurred later with T-90. Free insulin tends to decrease more during the pre-exercise period in the T-90 strategy (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.08). Although local muscle vasodilatation (\u0394THb) was comparable between the two strategies, we found that PG dropped more in cases of higher exercise-induced skeletal muscle vasodilatation (\u0394THb\u2009\u00d7\u2009time interaction\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.005,\n                      <jats:italic toggle=\"yes\">e<\/jats:italic>\n                      : \u22120.0086\u2009mM\/min and additional mM of \u0394THb).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>T-90 timing reduced exercise-induced drop in PG and delayed the occurrence of hypoglycemic episodes compared with T-40 timing without a significant reduction in the number of events requiring treatment.<\/jats:p>\n                    <jats:p>\n                      Trial registration:\n                      <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:uri>\n                      identifier: NCT03349489\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2021.0375","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T10:02:32Z","timestamp":1643623352000},"page":"307-315","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Anticipated Basal Insulin Reduction to Prevent Exercise-Induced Hypoglycemia in Adults and Adolescents Living with Type 1 Diabetes"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-2648","authenticated-orcid":false,"given":"S\u00e9mah","family":"Tagougui","sequence":"first","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM), Montreal, Canada."},{"name":"D\u00e9partement de nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 - URePSSS - Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Legault","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM), Montreal, Canada."},{"name":"McGill University Health Center (MUHC), Montreal Children's Hospital, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Heyman","sequence":"additional","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 - URePSSS - Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Messier","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Suppere","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Potter","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pigny","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie-Hormonologie, CHU Lille, Centre de Biologie-Pathologie, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Berthoin","sequence":"additional","affiliation":[{"name":"Univ. Lille, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, ULR 7369 - URePSSS - Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-430X","authenticated-orcid":false,"given":"Nadine","family":"Taleb","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM), Montreal, Canada."},{"name":"Division of Biomedical Sciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada."},{"name":"Endocrinology Division, Montreal Diabetes Research Center (MDRC), Montreal University Hospital (CHUM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-5170","authenticated-orcid":false,"given":"R\u00e9mi","family":"Rabasa-Lhoret","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM), Montreal, Canada."},{"name":"D\u00e9partement de nutrition, Universit\u00e9 de Montr\u00e9al, Montreal, Canada."},{"name":"Endocrinology Division, Montreal Diabetes Research Center (MDRC), Montreal University Hospital (CHUM), Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30014-1"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00818"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0720"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1728"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814566231"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2012.0168"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2021.01.003"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00818"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05244-y"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2018.08.002"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05263-9"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12552"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2204"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.414"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.6.2510"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1245"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2008.12.026"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199010000-00024"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000424"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00166.2018"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00674"},{"key":"e_1_3_5_23_2","first-page":"99","article-title":"Individual glucose responses to prolonged moderate intensity aerobic exercise in adolescents with type 1 diabetes: the higher they start, the harder they fall","volume":"20","author":"Riddell MC","year":"2019","unstructured":"Riddell MC, , Zaharieva DP, , Tansey M, et al.: Individual glucose responses to prolonged moderate intensity aerobic exercise in adolescents with type 1 diabetes: the higher they start, the harder they fall. 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