{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:35:38Z","timestamp":1788838538017,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Evaluating the feasibility of closed-loop insulin delivery with a zone model predictive control (zone-MPC) algorithm designed for pregnancy complicated by type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods:<\/jats:title>\n                    <jats:p>Pregnant women with T1D from 14 to 32 weeks gestation already using continuous glucose monitor (CGM) augmented pump therapy were enrolled in a 2-day multicenter supervised outpatient study evaluating pregnancy-specific zone-MPC based closed-loop control (CLC) with the interoperable artificial pancreas system (iAPS) running on an unlocked smartphone. Meals and activities were unrestricted. The primary outcome was the CGM percentage of time between 63 and 140\u2009mg\/dL compared with participants' 1-week run-in period. Early (2-h) postprandial glucose control was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eleven participants completed the study (age: 30.6\u2009\u00b1\u20094.1 years; gestational age: 20.7\u2009\u00b1\u20093.5 weeks; weight: 76.5\u2009\u00b1\u200915.3\u2009kg; hemoglobin A1c: 5.6%\u2009\u00b1\u20090.5% at enrollment). No serious adverse events occurred. Compared with the 1-week run-in, there was an increased percentage of time in 63\u2013140\u2009mg\/dL during supervised CLC (CLC: 81.5%, run-in: 64%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.007) with less time &gt;140\u2009mg\/dL (CLC: 16.5%, run-in: 30.8%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.029) and time &lt;63\u2009mg\/dL (CLC: 2.0%, run-in:5.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.039). There was also less time &lt;54\u2009mg\/dL (CLC: 0.7%, run-in:1.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.030) and &gt;180\u2009mg\/dL (CLC: 4.9%, run-in: 13.1%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.032). Overnight glucose control was comparable, except for less time &gt;250\u2009mg\/dL (CLC: 0%, run-in:3.9%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.030) and lower glucose standard deviation (CLC: 23.8\u2009mg\/dL, run-in:42.8\u2009mg\/dL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.007) during CLC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this pilot study, use of the pregnancy-specific zone-MPC was feasible in pregnant women with T1D. Although the duration of our study was short and the number of participants was small, our findings add to the limited data available on the use of CLC systems during pregnancy (NCT04492566).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2021.0521","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T10:30:09Z","timestamp":1646130609000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Feasibility of Closed-Loop Insulin Delivery with a Pregnancy-Specific Zone Model Predictive Control Algorithm"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-1892","authenticated-orcid":false,"given":"Basak","family":"Ozaslan","sequence":"first","affiliation":[{"name":"Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, Massachusetts, USA."},{"name":"Sansum Diabetes Research Institute, Santa Barbara, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol J.","family":"Levy","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-6622","authenticated-orcid":false,"given":"Yogish C.","family":"Kudva","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Pinsker","sequence":"additional","affiliation":[{"name":"Sansum Diabetes Research Institute, Santa Barbara, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grenye","family":"O'Malley","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder Jeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Castorino","sequence":"additional","affiliation":[{"name":"Sansum Diabetes Research Institute, Santa Barbara, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Levister","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari Charisse","family":"Trinidad","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Desjardins","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Mei","family":"Church","sequence":"additional","affiliation":[{"name":"Sansum Diabetes Research Institute, Santa Barbara, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Plesser","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"McCrady-Spitzer","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selassie","family":"Ogyaadu","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Nelson","sequence":"additional","affiliation":[{"name":"Sansum Diabetes Research Institute, Santa Barbara, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Reid","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Harvard John A. 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