{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:22:28Z","timestamp":1792142548359,"version":"4.4.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The RELIEF study has previously shown a fall in the rate of acute diabetes events (ADEs) in people living with type 1 diabetes (PwDT1) or people living with type 2 diabetes (PwDT2) in the 12 months after initiation of flash glucose monitoring (FLASH) in France. The 2-year follow-up has provided new insights on the frequency of ADEs, including severe hypoglycemia and diabetic ketoacidosis (DKA), during use of FLASH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The RELIEF study included 31,446 PwDT1 and 41,027 PwDT2 with a first delivery of FreeStyle Libre (FSL) between August 1 and December 31, 2017. Hospitalizations for DKA, severe hypoglycemia, diabetes-related coma, and hyperglycemia were recorded for the 12 months before and 24 months after FSL initiation. Persistence of the FSL system use was estimated through a Kaplan\u2013Meier survival curve. Change in usual blood glucose monitoring was estimated through acquisition of blood glucose test strips.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the 2 years after FSL initiation, hospitalizations for ADEs were reduced by 49% and by 48% in PwDT1 or PwDT2, respectively, driven by reductions in DKA. After 2 years, 88% of patients persisted with the system and estimated mean consumption of blood glucose test strips had fallen after 2 years by \u221282% and by \u221284% in type 1 diabetes mellitus and type 2 diabetes mellitus, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Use of FSL consistently reduces the rates of hospitalization for ADEs, mainly DKA, 2 years after initiation, confirming this is not a transitory effect. Use of FSL also results in a clear and progressive drop in use of blood glucose test strips over the 2-year period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2022.0085","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T12:18:57Z","timestamp":1653308337000},"page":"611-618","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":63,"title":["Reduced Rate of Acute Diabetes Events with Flash Glucose Monitoring Is Sustained for 2 Years After Initiation: Extended Outcomes from the RELIEF Study"],"prefix":"10.1177","volume":"24","author":[{"given":"Jean-Pierre","family":"Riveline","sequence":"first","affiliation":[{"name":"Institut Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, Universit\u00e9 de Paris Cit\u00e9, IMMEDIAB Laboratory, Paris, France."},{"name":"Service of Diabetology, Endocrinology and Nutrition, Lariboisi\u00e8re Hospital, F\u00e9deration de Diab\u00e9tologie, Assistance Publique - H\u00f4pitaux de Paris, Paris, France."},{"name":"Department of Diabetology and Endocrinology, Lariboisi\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Roussel","sequence":"additional","affiliation":[{"name":"Institut Necker Enfants Malades (INEM), INSERM U1151, CNRS UMR 8253, Universit\u00e9 de Paris Cit\u00e9, IMMEDIAB Laboratory, Paris, France."},{"name":"Department of Diabetology and Endocrinology, Lariboisi\u00e8re Hospital, Paris, France."},{"name":"Department of Diabetology, Endocrinology, and Nutrition, Bichat-Claude Bernard Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vicaut","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Fernand Vidal Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"de Pouvourville","sequence":"additional","affiliation":[{"name":"Department of Economics, ESSEC Business School, Cergy-Pontoise, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-4608","authenticated-orcid":false,"given":"Bruno","family":"Detournay","sequence":"additional","affiliation":[{"name":"CEMKA, Bourg-la-Reine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Emery","sequence":"additional","affiliation":[{"name":"CEMKA, Bourg-la-Reine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Levrat-Guillen","sequence":"additional","affiliation":[{"name":"Abbott Laboratories, Maidenhead, Berkshire, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Guerci","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, and Nutrition, Brabois Adult Hospital, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, 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