{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:59:35Z","timestamp":1788519575113,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To explore the impact of missing data on the accuracy of continuous glucose monitoring (CGM) metrics collected for a 2-week period in a clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods:<\/jats:title>\n                    <jats:p>\n                      Simulations were conducted to examine the effect of various patterns of missingness on the accuracy of CGM metrics as compared with a \u201ccomplete\u201d data set. The proportion of missing data, the \u201cblock size\u201d in which the data were missing, and the missing mechanism were modified for each \u201cscenario.\u201d The degree of agreement between simulated and \u201ctrue\u201d glycemic measures under each scenario was presented as\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Under all missing patterns,\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      declined as the proportion of missing data increased, however, as the \u201cblock size\u201d of missing data increased, the percentage of missing data had a more pronounced effect on the agreement between measures. For a 14-day CGM data set to be considered representative for percentage time in range (%TIR), at least 70% of CGM data should be available over at least 10 days (\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009&gt;\u20090.9). Skewed outcome measures, such as percentage time below range and coefficient of variation, were more affected by missing data than the less skewed measures (%TIR, percentage time above range, mean glucose).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Both the degree and pattern of missing data impact upon the accuracy of recommended CGM-derived glycemic measures. In planning research, an understanding of patterns of missing data in the study population is required to gauge the likely effects of missing data on outcome accuracy.<\/jats:p>\n                    <jats:p>Trial registration number: Australian New Zealand Clinic Trials Registry ACTRN12616000753459.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2022.0101","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T09:36:37Z","timestamp":1676972197000},"page":"356-362","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of Missing Data on the Accuracy of Glucose Metrics from Continuous Glucose Monitoring Assessed Over a 2-Week Period"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-1875","authenticated-orcid":false,"given":"Grant J.","family":"Smith","sequence":"first","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, Perth, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-1735","authenticated-orcid":false,"given":"Mary B.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, Perth, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Australia."},{"name":"Division of Paediatrics, Within the Medical School, The University of Western Australia, Perth, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"de Bock","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Otago, Christchurch, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Women's and Children's Hospital, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"King","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, John Hunter Children's Hospital, Newcastle, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey R.","family":"Ambler","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, The University of Sydney, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-489X","authenticated-orcid":false,"given":"Sybil A.","family":"McAuley","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Melbourne, Australia."},{"name":"Department of Endocrinology and Diabetes, St Vincent's Hospital, Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Keech","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Melbourne, Australia."},{"name":"Department of Endocrinology and Diabetes, St Vincent's Hospital, Melbourne, Australia."},{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-5473","authenticated-orcid":false,"given":"Elizabeth A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, Perth, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Australia."},{"name":"Division of Paediatrics, Within the Medical School, The University of Western Australia, Perth, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-4032","authenticated-orcid":false,"given":"David N.","family":"O'Neal","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Melbourne, Australia."},{"name":"Department of Endocrinology and Diabetes, St Vincent's Hospital, Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7989-1998","authenticated-orcid":false,"given":"Timothy W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, Perth, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Australia."},{"name":"Division of Paediatrics, Within the Medical School, The University of Western Australia, Perth, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Australian JDRF Closed Loop Research 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