{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:56:55Z","timestamp":1791057415595,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Evaluate the impact of the MiniMed\u2122 780G advanced hybrid closed-loop (AHCL) system on the glucose profile of pregnant women with type 1 diabetes (T1D) and maternal\u2013neonatal complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From April 2021 to September 2022, pregnant women with T1D treated with the AHCL system were included in an observational multicenter retrospective study. Continuous glucose monitoring parameters were analyzed monthly during pregnancy as well as maternal\u2013neonatal complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirteen pregnant women, including a twin pregnancy (age: 33\u2009\u00b1\u20093 years, hemoglobin A1c [HbA1c]: 7.3%\u2009\u00b1\u20090.7%, insulin doses: 0.72\u2009\u00b1\u20090.21\u2009U\/kg\/day) were analyzed. At delivery, gestational age was 37\u2009\u00b1\u20092 weeks. During first 2 weeks of pregnancy, time in range (TIR, 63\u2013140\u2009mg\/dL) was 46% (34\u201355) and increased to 54% (51\u201359) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01), 64% (48\u201368) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01), and 66% (60\u201370) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) during the first, second, and third trimester, respectively. During the night, TIR (63\u2013140\u2009mg\/dL) was &gt;70% throughout pregnancy. Time below the range &lt;63\u2009mg\/dL increased from 0.5% (0\u20132) to 1.3% (0.7\u20132.2), 2% (1.2\u20133.5) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and 1.3% (1.31\u20133) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05) during the first, second, and third trimester, respectively. At delivery, insulin doses increased to 0.89\u2009\u00b1\u20090.35 IU\/kg\/day (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01), and HbA1c decreased to 6.4%\u2009\u00b1\u20090.6% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.005). The reported carbohydrate amount increased from 167\u2009\u00b1\u2009363\u2009g\/d during early pregnancy to 243\u2009\u00b1\u2009106\u2009g\/d (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01) at delivery. The birthweight was 3134\u2009\u00b1\u2009711\u2009g, with 5\/14 macrosomia and 2\/14 neonatal hypoglycemia. Moreover, 5\/13 patients had a preeclampsia and 9\/13 a cesarean section, including three cases of scarred uterus. The Clinical Trial Registration number is: CE-2022-55.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The AHCL system provided good glucose control during pregnancy and recommendation targets were reached during the nocturnal period only. The maternal and neonatal complications remained high.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2023.0267","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T14:52:46Z","timestamp":1699887166000},"page":"893-901","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["MiniMed\n                    <sup>TM<\/sup>\n                    780G Advanced Hybrid Closed-Loop System Study in Pregnant Women with Type 1 Diabetes"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-9543","authenticated-orcid":false,"given":"Clara","family":"Guibert","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department, Diabetes, and Nutrition Department, University Hospital of Strasbourg, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Amoura","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes, and Nutrition Department, University Hospital of Strasbourg, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Rakotoarisoa","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes, and Nutrition Department, University Hospital of Strasbourg, Strasbourg, France."},{"name":"Regenerative Nanomedicine, Inserm UMR 1260, University of Strasbourg, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Plat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Hospital of Avignon, Avignon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Sonnet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital of Brest, Brest, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-8474","authenticated-orcid":false,"given":"Sandrine","family":"Lablanche","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Grenoble University Hospital, Grenoble Alpes University, Grenoble, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Tr\u00e9glia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Conception Hospital, Marseille University Hospital, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Sarde","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes, and Nutrition Department, Hospital of Rayettes, Martigues, 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