{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:07:26Z","timestamp":1778155646621,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims\/Hypotheses:<\/jats:title>\n                    <jats:p>To investigate the frequency and characteristics of partial remission in Swedish children with type 1 diabetes and whether the insulin delivery method, that is, continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDIs), affects incidence and duration of this period, 2007\u20132011. Factors that increase the proportion of subjects who enter partial remission and extend this period can improve long-term metabolic control and reduce the risk of severe hypoglycemia, improve quality of life, and, in the long run, reduce late complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Longitudinal data from 2007 to 2020 were extracted from the Swedish National Quality Register (SWEDIABKIDS) with all reported newly diagnosed children. Data on C-peptide from the participants in the Better Diabetes Diagnosis study from 2007 to 2010 were used. The definition of partial remission was insulin dose\u2013adjusted HbA1c: HbA1c (%) + [4 \u00d7 total daily insulin dose (U\/kg\/day)] \u22649.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 3887 patients, 56% were boys. More boys than girls were in partial remission throughout the follow-up period until 24 months after diabetes onset. Fewer children 0\u20136 years old had partial remission at 3 and 12 months but not at 24 months compared with older age-groups. A larger proportion of patients using CSII at 12 and 24 months remained in partial remission compared with those with MDI (37% vs. 33%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02 and 31% vs. 27%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01, respectively). The level of C-peptide was higher in the group with partial remission and mean HbA1c was lower (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Partial remission at 12 months after diabetes onset was associated with CSII (odds ratio [OR]: 1.39, confidence interval [CI]:1.13, 1.71), shorter diabetes duration (OR: 0.80, CI: 0.76, 0.84), and male sex (OR: 1.23, CI: 1.04, 1.46).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\/Interpretation:<\/jats:title>\n                    <jats:p>Insulin through MDI, longer duration of diabetes, and female sex were associated with lower frequency of partial remission. Use of CSII seems to contribute to longer partial remission among Swedish children with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2024.0112","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T11:39:20Z","timestamp":1717673960000},"page":"851-861","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Partial Clinical Remission of Type 1 Diabetes in Swedish Children: A Longitudinal Study from the Swedish National Quality Register (SWEDIABKIDS) and the Better Diabetes Diagnosis (BDD) Study"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-778X","authenticated-orcid":false,"given":"Anna-Lena","family":"Fureman","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Pediatrics, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Bladh","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Division of Children\u2019s and Women\u2019s Health, Link\u00f6ping University, Link\u00f6ping, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelie","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund, Lund University, Sk\u00e5nes University Hospital, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gun","family":"Forsander","sequence":"additional","affiliation":[{"name":"Queen Silvia Children\u2019s Hospital, Sahlgrenska University Hospital and Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Lilja","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Unit of Research, Education and Development, \u00d6stersund, Ume\u00e5 University, Umea, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Crown Princess Victoria Children\u2019s Hospital and Division of Pediatrics,Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Samuelsson","sequence":"additional","affiliation":[{"name":"Crown Princess Victoria Children\u2019s Hospital and Division of Pediatrics,Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"S\u00e4rnblad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences, \u00d6rebro University, and Department of Pediatrics, University Hospital \u00d6rebro, \u00d6rebro, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f6rn","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Pediatrics, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12734"},{"issue":"4","key":"e_1_3_5_3_2","first-page":"246","article-title":"Two-year prospective evaluation of the factors affecting honeymoon frequency and duration in children with insulin dependent diabetes mellitus: The key-role of age at diagnosis","volume":"15","author":"Lombardo F","year":"2002","unstructured":"Lombardo F, , Valenzise M, , Wasniewska M, et al. 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