{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:20:49Z","timestamp":1789863649071,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We assessed real-life glycemic outcomes and predictors of composite measures of optimal glycemic control in children and adolescents with type 1 diabetes (T1D) during their initial 12 months of the MiniMed\u2122 780G use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective observational multicenter study collected demographic, clinical, and 2-week 780G system data at five time points. Optimal glycemic control was defined as a composite glycemic control (CGC) score requiring the attainment of four recommended continuous glucose monitoring (CGM) targets, as well as the glycemia risk index (GRI) of hypoglycemia and hyperglycemia and composite CGM index (COGI). Outcome measures included longitudinal changes in multiple glycemic parameters and CGC, GRI, and COGI scores, as well as predictors of these optimal measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The cohort included 93 children, 43% girls, with a median age of 15.1 years (interquartile range [IQR] 12.9,17.0). A longitudinal analysis adjusted for age and socioeconomic index yielded a significant improvement in glycemic control for the entire cohort (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      <jats:sub>time<\/jats:sub>\n                      &lt; 0.001) after the transition to 780G. The mean hemoglobin A1c (HbA1c) (SE) was 8.65% (0.12) at baseline and dropped by &gt;1% after 1 year to 7.54% (0.14) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      <jats:sub>time<\/jats:sub>\n                      &lt; 0.001). Optimal glycemic control measures improved at 12 months post 780G; CGC improved by 5.6-fold (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and was attained by 24% of the participants, the GRI score improved by 10-fold (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009) and was achieved by 10% of them, and the COGI improved by 7.6-fold (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and was attained by 20% of them. Lower baseline HbA1c levels and increased adherence to Advanced Hybrid Closed-Loop (AHCL) usage were predictors of achieving optimal glycemic control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The AHCL 780G system enhances glycemic control in children and adolescents with T1D, demonstrating improvements in HbA1c and CGM metrics, albeit most participants did not achieve optimal glycemic control. This highlights yet ongoing challenges in diabetes management, emphasizing the need for continued proactive efforts on the part of health care professionals, youth, and caregivers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/dia.2024.0148","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:45:05Z","timestamp":1715942705000},"page":"869-880","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Real-Life Achievements of MiniMed 780G Advanced Closed-Loop System in Youth with Type 1 Diabetes: AWeSoMe Study Group Multicenter Prospective Trial"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-3250","authenticated-orcid":false,"given":"Noah","family":"Gruber","sequence":"first","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Center, Ramat-Gan, Israel."},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8701-5218","authenticated-orcid":false,"given":"Avigail","family":"Wittenberg","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."},{"name":"Pediatric Endocrinology and Diabetes Institute, Shamir (Assaf Harofeh) Medical Center, Beer Yakov, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-8264","authenticated-orcid":false,"given":"Avivit","family":"Brener","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."},{"name":"The Institute of Pediatric Endocrinology, Diabetes, and Metabolism, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirli","family":"Abiri","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."},{"name":"Pediatric Endocrine and Diabetes Unit, E. Wolfson Medical Center, Holon, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6153-598X","authenticated-orcid":false,"given":"Kineret","family":"Mazor-Aronovitch","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Center, Ramat-Gan, Israel."},{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."},{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Raanana, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-5033","authenticated-orcid":false,"given":"Michal","family":"Yackobovitch-Gavan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2958-6696","authenticated-orcid":false,"given":"Shay","family":"Averbuch","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Ben Ari","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel."},{"name":"The Institute of Pediatric Endocrinology, Diabetes, and Metabolism, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-8970","authenticated-orcid":false,"given":"Noah","family":"Levek","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Center, Ramat-Gan, Israel."},{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Raanana, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-3176","authenticated-orcid":false,"given":"Neriya","family":"Levran","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Chaim Sheba Medical Center, Ramat-Gan, Israel."},{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Raanana, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-9563","authenticated-orcid":false,"given":"Zohar","family":"Landau","sequence":"additional","affiliation":[{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Raanana, 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