{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:48:17Z","timestamp":1784638097597,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    To evaluate the long-term metabolic outcomes and safety of hybrid closed loop (HCL) in youth living with type 1 diabetes, including people with very poor metabolic control, this observational, retrospective, monocentric study included 101 patients aged 15\u201325 years. After a mean (\u00b1standard deviation; range) follow-up of 16 (\u00b16; 3\u201331) months, HbA1c decreased from 9.6%\u2009\u00b1\u20092.3% (82 \u00b1 25 mmol\/mol) at baseline to 8.0%\u2009\u00b1\u20091.4% (64 \u00b1 15 mmol\/mol) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). Continuous glucose monitoring parameters showed the same trend (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001): the glucose management indicator decreased from 8.8% to 7.9%, time in range increased from 39% to 57%, and time below range decreased from 3.0% to 1.6%. Ten patients discontinued HCL. There was no more severe hypoglycemia or diabetes ketoacidosis under HCL compared with the year before HCL initiation. Five cases of new onset and four cases of worsening retinopathy were reported. Youth with type 1 diabetes can improve metabolic control thanks to HCL without increasing complication risk. Vigilance is required for preexisting retinopathy monitoring.\n                  <\/jats:p>","DOI":"10.1089\/dia.2024.0528","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T13:06:48Z","timestamp":1744290408000},"page":"760-764","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Hybrid Closed Loop in Adolescents and Young Adults Living with Type 1 Diabetes: A Real-World Study"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2367-7669","authenticated-orcid":false,"given":"Marine","family":"Ung","sequence":"first","affiliation":[{"name":"Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil-Essonne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-7674","authenticated-orcid":false,"given":"Alfred","family":"Penfornis","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil-Essonne, France."},{"name":"Universit\u00e9 Paris-Saclay Facult\u00e9 de M\u00e9decine, Le Kremlin-Bicetre, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Valentim","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil-Essonne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Franc","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil-Essonne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Amadou","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil-Essonne, France."},{"name":"Universit\u00e9 Paris-Saclay Facult\u00e9 de M\u00e9decine, Le Kremlin-Bicetre, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Eroukhmanoff","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil-Essonne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S006"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13408"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0384"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac022"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30022-1"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0364"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0165"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0206"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-00996-7"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-2311"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15462"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2400185"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0334"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1243565"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0450"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0379"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05568-3"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0429"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(24)00002-5"}],"container-title":["Diabetes Technology &amp; 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