{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:02:11Z","timestamp":1792512131190,"version":"4.5.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Monogenic diabetes is a group of diseases that encompasses a growing number of genetic abnormalities affecting pancreatic function\/development leading to glycemic dysregulation. This includes conditions that have historically been referred to as maturity onset diabetes of the young or MODY in addition to neonatal diabetes mellitus. While recognition of a genetic or inherited form of diabetes has been known for decades, advances in molecular genetic testing have resulted in identification of specific forms of monogenic diabetes. Despite this, these genetic forms of diabetes remain widely underreported. It is important to be able to identify genetic forms of diabetes as treatment, monitoring for microvascular and macrovascular complications, and overall management varies for the different forms of monogenic diabetes. Furthermore, the identification of a specific monogenic form of diabetes can significantly impact the person\u2019s quality of life and other family members, as well as health care costs. This article highlights the identification, treatment, and management for various forms of monogenic diabetes and addresses some unmet needs in caring for people with monogenic forms of diabetes.<\/jats:p>","DOI":"10.1089\/dia.2024.0602","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T04:26:24Z","timestamp":1743654384000},"page":"675-686","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Review of Monogenic Diabetes: Clinical Features and Precision Medicine in Genetic Forms of Diabetes"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-1814","authenticated-orcid":false,"given":"Erin C.","family":"Cobry","sequence":"first","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora CO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K.","family":"Steck","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora CO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"Diabetes in America [Internet]","author":"Salguero MV","year":"2023","unstructured":"Salguero MV, , Arosemena M, , Pollin T, , Greeley SAW, , Naylor RN, , Letourneau-Freiberg L, et al. Monogenic Forms of Diabetes. In: Lawrence JM, , Casagrande SS, , Herman WH, , Wexler DJ, , Cefalu WT, editors. Diabetes in America [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); 2023. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK597414\/"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra002168"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0035"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.24.1.44"},{"issue":"170","key":"e_1_3_4_6_2","first-page":"339","article-title":"Mild familial diabetes with dominant inheritance","volume":"43","author":"Tattersall RB","year":"1974","unstructured":"Tattersall RB. Mild familial diabetes with dominant inheritance. Q J Med, 1974; 43(170):339\u2013357.","journal-title":"Q J Med"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000354219"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13426"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12289"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0574"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00025-6"},{"key":"e_1_3_4_12_2","unstructured":"CDC. Diabetes. 2024 About Type 2 Diabetes. Available from: https:\/\/www.cdc.gov\/diabetes\/about\/about-type-2-diabetes.html [Last accessed: September11 2024]."},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0645"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1279"},{"issue":"3","key":"e_1_3_4_15_2","first-page":"174","article-title":"Permanent neonatal diabetes mellitus: Prevalence and genetic diagnosis in the SEARCH for diabetes in youth study","volume":"14","author":"Kanakatti Shankar R","year":"2013","unstructured":"Kanakatti Shankar R, , Pihoker C, , Dolan LM, et al.; SEARCH for Diabetes in Youth Study Group. Permanent neonatal diabetes mellitus: Prevalence and genetic diagnosis in the SEARCH for diabetes in youth study. Pediatr Diabetes, 2013; 14(3):174\u2013180.","journal-title":"Pediatr Diabetes"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-0491"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0261"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-023-00369-8"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0317"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2056"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2769"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2248"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00530.x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v15.i1.15"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S186610"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13180"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.283980"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa710"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S002"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.829565"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v14.i12.1738"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13860"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0058"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-209163"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02138-x"},{"issue":"3","key":"e_1_3_4_36_2","first-page":"81","article-title":"Liver adenomatosis and Maturity-Onset Diabetes of the Young (MODY) type 3 due to HNF1A mutation not previously described","volume":"4","author":"Alemany M","year":"2014","unstructured":"Alemany M, , del C, , de M, et al. Liver adenomatosis and Maturity-Onset Diabetes of the Young (MODY) type 3 due to HNF1A mutation not previously described. Journal of Endocrinology and Metabolism, 2014; 4(3):81\u201385.","journal-title":"Journal of Endocrinology and Metabolism"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0288"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1314"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-3007"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040118"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0012"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1237553"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2015.12.005"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2016.10.003"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01696"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031828"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01999.x"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0331-8"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.02965.x"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2017.10.006"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0029"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60098-8"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2013.18.3.148"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.04.007"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-024-01653-z"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1196"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055068"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23995"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2319-x"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30106-2"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13376"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3921-8"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3593-9"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12599"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101280"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707291104"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00356"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12635"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2494"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1188"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2021.2021.0005"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13011"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0061"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2826"},{"key":"e_1_3_4_75_2","first-page":"193229682413108","article-title":"Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT)","author":"McCullough ME","year":"2025","unstructured":"McCullough ME, , Letourneau-Freiberg LR, , Naylor RN, et al. Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT). J Diabetes Sci Technol, 2025:19322968241310896.","journal-title":"J Diabetes Sci Technol"},{"key":"e_1_3_4_76_2","unstructured":"Monogenic Diabetes Gene Curation Expert Panel - ClinGen | Clinical Genome Resource. Available from: https:\/\/clingen.info\/affiliation\/40016\/ [Last accessed: September25 2024]."},{"key":"e_1_3_4_77_2","unstructured":"Monogenic Diabetes Variant Curation Expert Panel\u2014ClinGen | Clinical Genome Resource. Available from: https:\/\/clinicalgenome.org\/affiliation\/50016\/ [Last accessed: September25 2024]."},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-022-01972-2"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dia.2024.0602","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2024.0602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2024.0602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:15:18Z","timestamp":1777400118000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dia.2024.0602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":77,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1089\/dia.2024.0602"],"URL":"https:\/\/doi.org\/10.1089\/dia.2024.0602","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}