{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:08:42Z","timestamp":1779106122231,"version":"3.51.4"},"reference-count":101,"publisher":"SAGE Publications","issue":"3_suppl","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Technology &amp; Therapeutics"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1089\/dia.2025.0134","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T10:01:23Z","timestamp":1751364083000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Artificial Pancreas: The First 20 Years*"],"prefix":"10.1177","volume":"27","author":[{"suffix":"III","given":"Francis J.","family":"Doyle","sequence":"first","affiliation":[{"name":"School of Engineering, Brown University, Providence, Rhode Island, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-3901","authenticated-orcid":false,"given":"Boris P.","family":"Kovatchev","sequence":"additional","affiliation":[{"name":"University of Virginia, Center for Diabetes Technology, Charlottesville, Virginia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"Chapter 1: Components and Integration: CGMs Insulin and AP Systems."},{"key":"e_1_3_5_3_2","unstructured":"Chapter 2: Metabolic Models In Silico Trials and Algorithms."},{"key":"e_1_3_5_4_2","unstructured":"Chapter 3: Early stages of Automatic Insulin Delivery."},{"key":"e_1_3_5_5_2","unstructured":"Chapter 4: Registration Studies and Real-Life Data."},{"key":"e_1_3_5_6_2","unstructured":"Chapter 5: Pitfalls Research Gaps Challenges and Opportunities."},{"key":"e_1_3_5_7_2","unstructured":"Chapter 6: Practical Considerations and Implementation of AID Systems."},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6107.204"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197903153001101"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.740877"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/15209150050214078"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/152091503322526978"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/152091504774197990"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0419"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0467"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1134"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.01.06.dc05-1686"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805017"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1231"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01672.x"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229680700100112"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2008.0032"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200518"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1445"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0948"},{"key":"e_1_3_5_26_2","first-page":"A187","article-title":"Clinical insights from preliminary testing of an artificial \u03b2-cell control algorithm\u2014modeling and tuning. In: Klonoff DC. Summary of Seventh Annual Diabetes Technology Meeting October 25-27, 2007 San Francisco, California","volume":"2","author":"Zisser H","year":"2008","unstructured":"Zisser H, , Palerm C, , Finan D, et al. Clinical insights from preliminary testing of an artificial \u03b2-cell control algorithm\u2014modeling and tuning. In: Klonoff DC. Summary of Seventh Annual Diabetes Technology Meeting October 25-27, 2007 San Francisco, California. J Diabetes Sci Technol, 2008; 2:A187.","journal-title":"J Diabetes Sci Technol"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231195081"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206881"},{"issue":"3","key":"e_1_3_5_29_2","first-page":"159","article-title":"The \u201cglucositter\u201d overnight automated closed loop system for type 1 diabetes: A randomized crossover trial","volume":"14","author":"Nimri R","year":"2013","unstructured":"Nimri R, , Danne T, , Kordonouri O, et al. The \u201cglucositter\u201d overnight automated closed loop system for type 1 diabetes: A randomized crossover trial. Pediatr Diabetes, 2013; 14(3):159\u2013167.","journal-title":"Pediatr Diabetes"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.478"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/485S6a"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.343.6167.133"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700602"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700603"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0660"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1965"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2076"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2468"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0008"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2815"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0333"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0018"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0883"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2108"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0824"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2078"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602494"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0479"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30280-7"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11708"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30167-5"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1310"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05391-w"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2021.0177"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1907863"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004736"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203913"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2210834"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2205225"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203496"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303911"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15196"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0569"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968241274786"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0203"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2024.0148"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0348"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0433"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0097"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-1217"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15086"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0341"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0337"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0578"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0323"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00089-5"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-0173"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0267"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0594"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0178"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0509"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2024.0048"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0262"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0009"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0324"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231204884"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-0470"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-0685"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231182406"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968241245627"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0018"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05744-z"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac022"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1177\/19322968231201829"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10119"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0031"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00190.2001"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2007.893506"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2009.2036073"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2023.3331297"},{"key":"e_1_3_5_101_2","article-title":"Deep Neural network architectures for an embedded MPC implementation: Application to an automated insulin delivery system","author":"Castillo A","year":"2023","unstructured":"Castillo A, , Villa-Tamayo MF, , Pryor E, et al. Deep Neural network architectures for an embedded MPC implementation: Application to an automated insulin delivery system. 22nd IFAC World Congress, 2023.","journal-title":"22nd IFAC World Congress"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0469"}],"container-title":["Diabetes Technology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dia.2025.0134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2025.0134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2025.0134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:12:34Z","timestamp":1779102754000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dia.2025.0134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":101,"journal-issue":{"issue":"3_suppl","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1089\/dia.2025.0134"],"URL":"https:\/\/doi.org\/10.1089\/dia.2025.0134","relation":{},"ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}