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Several commercially available AP systems operate in hybrid closed-loop mode that requires manual information from the user for meals and exercise. This article summarizes the progress on mathematical models of glucose-insulin dynamics, continuous glucose monitoring systems, and insulin pumps that form the building blocks of AP systems, the shift from animal studies to in silico clinical trials that accelerated the rate of progress in AP technologies and the efforts for developing the next-generation AP systems, and the fully automated AP that eliminates manual inputs and mitigates the effects of disturbances to glucose homeostasis\u2014meals, physical activities, acute stress, and variations in sleep characteristics. 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