{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:40:24Z","timestamp":1781106024840,"version":"3.54.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:p>\n                    To establish immunologic autotolerance, self-reactive immature thymocytes are eliminated by negative selection during T-cell development in the thymus. Self-reactive clones undergo apoptosis after stimulation via the T-cell receptor (TCR). The process of cell selection is determined by the dedication of the TCR for tolerogenic antigen\/major histocompatibility complex. We have cloned a novel human gene that is highly homologous in the transmembrane and G protein-coupling domains to mouse T-cell death-associated gene 8 (TDAG8). The gene, human\n                    <jats:italic toggle=\"yes\">TDAG8 (hTDAG8)<\/jats:italic>\n                    , which belongs to the G protein-couple receptor superfamily, encodes a protein of 337 amino acids. An expressed sequence tag (EST) corresponding to\n                    <jats:italic toggle=\"yes\">hTDAG8<\/jats:italic>\n                    was identified from a human thyroid cDNA library and subsequently used to isolate a full-length genomic clone. Northern blot analysis revealed that the\n                    <jats:italic toggle=\"yes\">hTDAG8<\/jats:italic>\n                    gene is expressed predominantly in lymphoid tissues, including peripheral blood leukocytes, spleen, lymph nodes, and thymus. Stably transfected mammalian CHO cells were generated, and heterologous expression of\n                    <jats:italic toggle=\"yes\">hTDAG8<\/jats:italic>\n                    was confirmed by Northern blot analysis. Fluorescent\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization (FISH) revealed that\n                    <jats:italic toggle=\"yes\">hTDAG8<\/jats:italic>\n                    maps to human chromosome 14q31-32.1, a region in which abnormalities associated with human T-cell lymphoma or leukemia are found. Taken together, these data implicate the\n                    <jats:italic toggle=\"yes\">hTDAG8<\/jats:italic>\n                    gene in T-cell-associated diseases in humans, but its actual physiological and pathological role in the human immune system needs further investigation.\n                  <\/jats:p>","DOI":"10.1089\/dna.1998.17.493","type":"journal-article","created":{"date-parts":[[2009,3,23]],"date-time":"2009-03-23T14:02:56Z","timestamp":1237816976000},"page":"493-500","source":"Crossref","is-referenced-by-count":53,"title":["Cloning, Characterization, and Mapping of Human Homolog of Mouse T-Cell Death-Associated Gene"],"prefix":"10.1177","volume":"17","author":[{"given":"Hla","family":"Kyaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"SU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda K.","family":"Shell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YI","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,6,1]]},"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.1998.17.493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.1998.17.493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:11:51Z","timestamp":1773241911000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dna.1998.17.493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["10.1089\/dna.1998.17.493"],"URL":"https:\/\/doi.org\/10.1089\/dna.1998.17.493","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6]]}}}