{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:32:01Z","timestamp":1773307921923,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>\n                    Alterations of the human epidermal growth factor receptor 2 (\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    ) protooncogene have been implicated in the carcinogenesis and prognosis of breast cancer. A polymorphism has been identified at codon 655 (ATC\/isoleucine to GTC\/valine [I655V]) in the transmembrane domain-coding region of this gene, which may be associated with the risk of breast cancer. In this study we aimed to determine whether the risk of breast cancer is associated with the I655V polymorphism of\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    transmembrane domain-coding region at codon 655. The genomic DNA from breast cancer patients and control subjects underwent analysis by the polymerase chain reaction\u2013fragment length polymorphism. We observed no overall association between\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    genotype and breast cancer (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.53). However, an elevated positive association was observed for Ile\/Val+Val\/Val versus Ile\/Ile genotypes in women &gt;age 60 years (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.02). Further, other risk factors\u2014namely, the body mass index and family history\u2014were found to be risk factors for developing breast cancer (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.006 and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.00, respectively). In conclusion, results of this study suggest that polymorphisms of the\n                    <jats:italic toggle=\"yes\">HER2<\/jats:italic>\n                    gene may be important susceptibility biomarkers for breast cancer risk among older women.\n                  <\/jats:p>","DOI":"10.1089\/dna.2007.0702","type":"journal-article","created":{"date-parts":[[2008,8,23]],"date-time":"2008-08-23T10:00:19Z","timestamp":1219485619000},"page":"575-579","source":"Crossref","is-referenced-by-count":13,"title":["The Influence of\n                    <i>HER2<\/i>\n                    Genotypes as Molecular Markers on Breast Cancer Outcome"],"prefix":"10.1177","volume":"27","author":[{"given":"Hicran","family":"Mutluhan","sequence":"first","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etem","family":"Akbas","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazan Eras","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Soylemez","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet S\u0131dd\u0131k","family":"Senli","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilter","family":"Helvac\u0131","sequence":"additional","affiliation":[{"name":"Department of Statistics, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertugrul","family":"Seyrek","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Mersin University, Mersin, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,10,1]]},"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2007.0702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2007.0702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:11:23Z","timestamp":1773241883000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dna.2007.0702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1089\/dna.2007.0702"],"URL":"https:\/\/doi.org\/10.1089\/dna.2007.0702","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}