{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:30:58Z","timestamp":1777552258844,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    We explored the role of the C-160A single-nucleotide polymorphism (SNP) of\n                    <jats:italic toggle=\"yes\">CDH1<\/jats:italic>\n                    in susceptibility to gastric cancer through a systematic review and meta-analysis. Fourteen studies were included, the original groups collapsed, and re-grouped in accordance with the most appropriate genetic model. Potential sources of heterogeneity were sought out via subgroup analyses and sensitivity analyses, and publication biases were estimated. No significant association of C-160A was found with the overall risk of developing gastric cancer, but the apparently opposite tendency was noted between Caucasians and Asians, and a statistically significant association was found among Asians. The seemingly opposite tendency of associations was also seen between noncardia and cardia types or between sporadic diffuse and intestinal types of gastric cancer, but no statistically significant findings were noted. Genotyping techniques, sample size, quality appraisal scores, or article publication time did not constitute the source of heterogeneity across studies; and no publication biases were found in our meta-analysis.\n                  <\/jats:p>","DOI":"10.1089\/dna.2011.1257","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T13:39:34Z","timestamp":1306330774000},"page":"937-945","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["A Meta-Analysis of\n                    <i>CDH1<\/i>\n                    C-160A Genetic Polymorphism and Gastric Cancer Risk"],"prefix":"10.1177","volume":"30","author":[{"given":"Yun","family":"Cui","sequence":"first","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiping","family":"Xue","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Lin","sequence":"additional","affiliation":[{"name":"Fudan University School of Medicine","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihua","family":"Ni","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i27.3432"},{"key":"e_1_3_4_3_1","first-page":"2225","article-title":"Promoter polymorphisms and methylation of E-cadherin (CDH1) and KIT in gastric cancer patients from northern Brazil","volume":"30","author":"Borges Bdo N.","year":"2010","unstructured":"Borges Bdo N., , Santos Eda S., , Bastos C.E., , Pinto L.C., , Anselmo N.P., , Quaresma J.A., , Calcagno D.Q., , Burbano R.M., , Harada M.L. 2010. Promoter polymorphisms and methylation of E-cadherin (CDH1) and KIT in gastric cancer patients from northern Brazil. Anticancer Res, 30:2225\u20132233.","journal-title":"Anticancer Res"},{"key":"e_1_3_4_4_1","first-page":"2916","article-title":"Decreased expression of E-cadherin in the progression of rat prostatic cancer","volume":"52","author":"Bussemakers M.J.","year":"1992","unstructured":"Bussemakers M.J., , van Moorselaar R.J., , Giroldi L.A., , Ichikawa T., , Isaacs J.T., , Takeichi M., , Debruyne F.M., , Schalken J.A. 1992. Decreased expression of E-cadherin in the progression of rat prostatic cancer. Cancer Res, 52:2916\u20132922.","journal-title":"Cancer Res"},{"key":"e_1_3_4_5_1","first-page":"1270","article-title":"CDH1 C-160A promoter polymorphism and genetic susceptibility to gastric cancer: a meta-analysis","volume":"18","author":"Cao W.J.","year":"2010","unstructured":"Cao W.J., , Zhang Z.Y., , Yue Q.Y. 2010. 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Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan. Int J Oncol, 23:421\u2013427.","journal-title":"Int J Oncol"},{"key":"e_1_3_4_16_1","first-page":"873","article-title":"A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities","volume":"60","author":"Li L.C.","year":"2000","unstructured":"Li L.C., , Chui R.M., , Sasaki M., , Nakajima K., , Perinchery G., , Au H.C., , Nojima D., , Carroll P., , Dahiya R. 2000. A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. 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