{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:36:24Z","timestamp":1777552584831,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Atrial septal defect (ASD) is a common type of congenital heart disease, which is defined as any communication through atrial septum. Several studies have revealed that genetic factors may influence the susceptibility of ASD. Recent studies have shown that\n                    <jats:italic toggle=\"yes\">reticulon 4<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">RTN4<\/jats:italic>\n                    ) gene might be involved in some processes relevant to heart development, such as regulation of cell migration and vascular remodeling. This study aimed to evaluate\n                    <jats:italic toggle=\"yes\">RTN4<\/jats:italic>\n                    gene polymorphisms of CAA and TATC insertion\/deletion in relation to the risk of ASD in Chinese Han population. A total of 175 ASD patients and 308 unrelated healthy controls were successfully investigated. The polymorphisms of patients were determined by polymerase chain reaction\u2013polyacrylamide gel electrophoresis. There was no significant difference in the allele frequencies of CAA and TATC insertion\/deletion in\n                    <jats:italic toggle=\"yes\">RNT4<\/jats:italic>\n                    gene between ASD patients and controls. The same results were seen in their genotypes. The present study suggests that CAA and TATC insertion\/deletion polymorphisms of\n                    <jats:italic toggle=\"yes\">RNT4<\/jats:italic>\n                    gene may not be a useful marker to predict the susceptibility of ASD in Chinese Han population.\n                  <\/jats:p>","DOI":"10.1089\/dna.2011.1386","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T11:42:15Z","timestamp":1328614935000},"page":"1121-1124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["RNT4 3\u2032-UTR Insertion\/Deletion Polymorphisms Are Not Associated with Atrial Septal Defect in Chinese Han Population: A Brief Communication"],"prefix":"10.1177","volume":"31","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"West China Hospital of Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"West China Second University Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Bai","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Rao","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,6,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1020"},{"key":"e_1_3_3_3_1","first-page":"530","article-title":"E1983\u00a3\u00a9TGFB2 and TGFB3 Have Separate and Sequential Activities during Epithelial Mesenchymal Cell Transformation in the Embryonic Heart","volume":"208","author":"Angelique S.","unstructured":"Angelique S., , Boyer, , Ingrid I., , Ayerinskas, , Eric B., , Vincent, , Lisa A., , McKinney, , Daniel L., , Weeks, , Raymond B., , Runyan. E1983\u00a3\u00a9TGFB2 and TGFB3 Have Separate and Sequential Activities during Epithelial Mesenchymal Cell Transformation in the Embryonic Heart. Development Biology, 208:530\u2013545.","journal-title":"Development Biology"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.2919"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01596"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000219"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2010.1116"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/76211"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001660105"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.1.1"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00420-0"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01827"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03553.2002"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.02.024"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1125"},{"key":"e_1_3_3_16_1","first-page":"696","article-title":"Mutation of NKX2-5 gene in patients with atrial septal defect","volume":"47","author":"Liu X.Y.","year":"2009","unstructured":"Liu X.Y., , Yang Y.Q., , Yang Y., , Lin X.P., , Chen Y.H. 2009. Mutation of NKX2-5 gene in patients with atrial septal defect. Zhonghua Er Ke Za Zhi, 47:696\u2013700.","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00583-9"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004221"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(02)00492-8"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)01179-8"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20116"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(05)43005-3"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.183056"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290272"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025190"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/77146"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207419"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000015499"},{"key":"e_1_3_3_29_1","first-page":"1128","article-title":"Incidence of congenital heart disease in Beijing, China","volume":"122","author":"Yang X.Y.","year":"2009","unstructured":"Yang X.Y., , Li X.F., , Lu X.D., , Liu Y.L. 2009. Incidence of congenital heart disease in Beijing, China. 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