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A key part of atherosclerosis is the failure of macrophages to restore their cellular cholesterol homeostasis and the formation of foam cells. In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels. Curcumin activated AMP-activated protein kinase (AMPK) and SIRT1, and then activated LXR\u03b1 in THP-1 macrophage-derived foam cells. Inhibiting AMPK\/SIRT1 activity by its specific inhibitor or by small interfering RNA could inhibit LXR\u03b1 activation and abolish curcumin-induced ABCA1 expression and cholesterol efflux. Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXR\u03b1 signaling in THP-1 macrophage-derived foam cells. This study describes a possible mechanism for understanding the antiatherogenic effects of curcumin on attenuating the progression of atherosclerosis.\n                  <\/jats:p>","DOI":"10.1089\/dna.2015.2866","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T11:38:07Z","timestamp":1435059487000},"page":"561-572","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":84,"title":["Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXR\u03b1 Signaling in THP-1 Macrophage-Derived Foam Cells"],"prefix":"10.1177","volume":"34","author":[{"given":"Xiao-long","family":"Lin","sequence":"first","affiliation":[{"name":"Guangzhou Medical University Huizhou City","place":["People's Republic of China"]},{"name":"University of South China","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"University of South China","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University Huizhou City","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-ru","family":"Feng","sequence":"additional","affiliation":[{"name":"Hebei Medical University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University Huizhou City","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-wen","family":"Zou","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University Huizhou City","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-quan","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University Huizhou City","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-mei","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University Huizhou City","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo","family":"Wang","sequence":"additional","affiliation":[{"name":"University of South China","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303383"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0266-2"},{"key":"e_1_3_3_4_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A PPAR gamma-lxrabca1 pathway in macrophages is involved in cholesterol efflux and atherogenesis","volume":"7","author":"Chawla A.","year":"2001","unstructured":"Chawla A., , Boisvert W.A., , Lee C.H., et al. 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