{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:25:26Z","timestamp":1777551926330,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n                    To investigate the therapeutic mechanisms underlying prostaglandin E1 (PGE1) and angiotensin-converting enzyme inhibitor (ACEI) on reducing urinary protein in diabetic kidney disease (DKD). DKD rats were established and randomly divided into four groups: PGE1 (10\u2009\u03bcg\/kg\/day) (P group), ACEI (10\u2009mg\/kg\/day) (A group), combination of PGE1 with ACEI treatment (P\u2009+\u2009A group), and saline treatment group (DKD group). Untreated rats were used as normal control (N group). Urinary albumin, endothelin-1 (ET-1), angiotensin II (AngII), TUNEL assay, Masson's trichrome staining, and immunohistochemistry staining for CD68 were evaluated in all groups. Ten days after treatment, urinary albumin was significantly decreased in the P and P\u2009+\u2009A groups (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01 vs. the DKD group\n                    <jats:italic toggle=\"yes\">)<\/jats:italic>\n                    . At the end of 8 weeks, the albumin was still significantly reduced in the P\u2009+\u2009A group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05 vs. the A group). ET-1 and AngII were also significantly decreased in three treatment groups (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01 vs. the DKD group), especially in the P\u2009+\u2009A group. Few cells underwent apoptosis in glomerular regions in DKD rats, while amounts of apoptotic cells were seen in tubules regions. Further, apoptosis and the areas of fibrosis in tubulointerstitial were both decreased most in the P\u2009+\u2009A group compared with the DKD group. Apoptosis of renal tubular epithelial cells may participate in the development and progression of DKD in rats. Combination of PGE1 with AGEI remarkably protects renal function compared with PGE1 or ACEI monotherapy. The potential therapeutic mechanisms of PGE1 and AGEI might be via multiple targets and, at least in part, through inhibiting the apoptosis of renal tubular epithelial cells.\n                  <\/jats:p>","DOI":"10.1089\/dna.2017.3690","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T10:17:18Z","timestamp":1511950638000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrated Treatment of Prostaglandin E1 and Angiotensin-Converting Enzyme Inhibitor in Diabetic Kidney Disease Rats: Possible Role of Antiapoptosis in Renal Tubular Epithelial Cells"],"prefix":"10.1177","volume":"37","author":[{"given":"Yaru","family":"Mou","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Guo","sequence":"additional","affiliation":[{"name":"Shandong University","place":["China"]},{"name":"Shandong University of Traditional Chinese Medicine","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shandong University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Dong","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liao","sequence":"additional","affiliation":[{"name":"Shandong University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.7646"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181ad2190"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11321112"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339910790909422"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2012.07.008"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2016.3276"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1285104"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148542"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00173.2005"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.148"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004110973"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2011.04.021"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076749"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000135055.61833.A8"},{"key":"e_1_3_3_16_1","first-page":"482","article-title":"Therapeutic effect of prostaglandin E1 on diabetic nephropathy: a one-year follow-up study","volume":"30","author":"Li P.F.","year":"2010","unstructured":"Li P.F., , Mu Y.R., , Xin Y., , Qu Y., , and Liao L. 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