{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:45:50Z","timestamp":1790138750858,"version":"4.0.1"},"reference-count":70,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>The high cost of drug development and the narrow spectrum of coverage typically provided by direct-acting antivirals limit the scalability of this antiviral approach. This review summarizes progress and challenges in the repurposing of approved kinase inhibitors as host-targeted broad-spectrum antiviral therapies.<\/jats:p>","DOI":"10.1089\/dna.2017.4033","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T15:47:40Z","timestamp":1510933660000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":87,"title":["Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs"],"prefix":"10.1177","volume":"37","author":[{"given":"Stanford","family":"Schor","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine"},{"name":"Stanford University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirit","family":"Einav","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine"},{"name":"Stanford University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2012.03.004"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv363"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89857"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1855"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000446200"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057340"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611681104"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.03.010"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.035"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00632-13"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00750-12"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01242-08"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03036-14"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00713.x"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001099"},{"key":"e_1_3_3_17_1","first-page":"123ra124","article-title":"Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase","author":"Garcia M.","year":"2012","unstructured":"Garcia M., , Cooper A., , Shi W., , Bornmann W., , Carrion R., , Kalman D., , and Nabel G.J. (2012). Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase. Sci Transl Med 4, 123ra124.","journal-title":"Sci Transl Med 4,"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02196-09"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76094"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-7-7"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503312200"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606109103"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.03.017"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.18.11943-11951.2005"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12948"},{"key":"e_1_3_3_26_1","first-page":"2229","article-title":"A high throughput RNAi screen reveals determinants of HIV-1 activity in host kinases","volume":"7","author":"Jiang W.-M.","year":"2014","unstructured":"Jiang W.-M., , Zhang X.-Y., , Zhang Y.-Z., , Liu L., , and Lu H.-Z. (2014). A high throughput RNAi screen reveals determinants of HIV-1 activity in host kinases. Int J Clin Exp Pathol, 7, 2229\u20132237.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.04.014"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12029"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1358"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.722"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03659-14"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2787"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.20303"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30490"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2010.11.006"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi034369n"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907439106"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3190"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182007be2"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2341"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.8742-8749.2005"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032561"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711794839188"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002845"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02705-14"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.10.99"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v2.i2.71"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000399"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400873"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2015.0003.drrr"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/35060098"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01814-10"},{"key":"e_1_3_3_53_1","first-page":"103","article-title":"The cell cycle, cyclin-dependent kinases, and viral infections: new horizons and unexpected connections","volume":"5","author":"Schang L.M.","year":"2003","unstructured":"Schang L.M. (2003). The cell cycle, cyclin-dependent kinases, and viral infections: new horizons and unexpected connections. Prog Cell Cycle Res, 5, 103\u2013124.","journal-title":"Prog Cell Cycle Res"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020601700601"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.01.154"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01323-14"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703988200"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00129-10"},{"key":"e_1_3_3_59_1","unstructured":"Tufts Center for the Study of Drug Development. (2014). Cost to develop and win 279 marketing approval for a new drug is $2.6 billion. [online] Available at: http:\/\/csdd.tufts.edu\/news\/complete_story\/pr_tufts_csdd_2014_cost_study (accessed October10 2017)."},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121401"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053979"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1236"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01818"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2145"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200503173521125"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4184"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73805"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.4.3460-3466.1999"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01586-06"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1796"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.02.006"}],"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dna.2017.4033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2017.4033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2017.4033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:56:22Z","timestamp":1777398982000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dna.2017.4033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1089\/dna.2017.4033"],"URL":"https:\/\/doi.org\/10.1089\/dna.2017.4033","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}