{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:26:50Z","timestamp":1788190010805,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    There is a perception that long noncoding RNA (lncRNA) has relationship with carcinogenesis. Many studies have previously identified and validated that the section of chromosome 11p13 is associated with high incidence of tumor. In this study, we investigated a new lncRNA, named\n                    <jats:italic toggle=\"yes\">lncPRRG4-4<\/jats:italic>\n                    , mapped to 11p13 and suspected that\n                    <jats:italic toggle=\"yes\">lncPRRG4-4<\/jats:italic>\n                    was a potential lung cancer-related gene. To explore its role in carcinogenesis, we first demonstrated that\n                    <jats:italic toggle=\"yes\">lncPRRG4-4<\/jats:italic>\n                    was upregulated in lung cancer tissues compared with adjacent nontumor tissues and functioned as an oncogene in lung cancer cells. The\n                    <jats:italic toggle=\"yes\">lncPRRG4-4<\/jats:italic>\n                    was significantly upregulated in lung cancer tissues compared with adjacent normal counterparts (mean\u2009\u00b1\u2009standard deviation: 0.12\u2009\u00b1\u20090.84 vs. 0.05\u2009\u00b1\u20090.22;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Patients with metastasis exhibited high levels of\n                    <jats:italic toggle=\"yes\">lncPRRG4-4<\/jats:italic>\n                    expression than those without metastasis in both the southern samples (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.045) and eastern samples (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.030), total samples (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004). In addition, downregulation of\n                    <jats:italic toggle=\"yes\">lncPRRG4-4<\/jats:italic>\n                    expression inhibited lung cancer proliferation, viability, migration, and invasion ability, arrested cell cycle, facilitated apoptosis, and\n                    <jats:italic toggle=\"yes\">vice versa<\/jats:italic>\n                    . Taken together, these observations suggested that the\n                    <jats:italic toggle=\"yes\">lncPRRG4-4<\/jats:italic>\n                    functions as an oncogene in lung cancer cells.\n                  <\/jats:p>","DOI":"10.1089\/dna.2018.4220","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T10:33:32Z","timestamp":1540550012000},"page":"953-966","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Long Noncoding RNA PRRG4-4 Promotes Viability, Cell Cycle, Migration, and Invasion in Lung Cancer Cells"],"prefix":"10.1177","volume":"37","author":[{"given":"Yuanyuan","family":"Wang","sequence":"first","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gong","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."},{"name":"The School of Public Health, The Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuman","family":"Qiu","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Lin","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpeng","family":"Su","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Nie","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Datta","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqi","family":"Rao","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Xian","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Feng","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The School of Public Health, The Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Genetics, Medical College of Soochow University, Suzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingcheng","family":"Gao","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."},{"name":"The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachun","family":"Lu","sequence":"additional","affiliation":[{"name":"The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."},{"name":"The School of Public Health, The Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, Guangzhou Medical University, Guangzhou, 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